ArticleThe Journal of surgical research2012
Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction.
Article in The Journal of surgical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial.Oxidative medicine and cellular longevity · 2018Trial
- Moderate Wine Consumption and Health: A Narrative Review.Nutrients · 2022Review
- Oxidative Stress Parameters in the Liver of Growing Male Rats Receiving Various Alcoholic Beverages.Nutrients · 2020Article
- Alcohol attenuates myocardial ischemic injury.Surgery · 2017Article
- Ethanol promotes new vessel growth in remote nonischemic myocardium.The Journal of surgical research · 2015Article
- Alcohol consumption mitigates apoptosis and mammalian target of rapamycin signaling in myocardium.Journal of the American College of Surgeons · 2014Article
- Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium.Circulation · 2013Article
- Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE.Prostaglandins & other lipid mediatorsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundModerate alcohol consumption is largely believed to be cardioprotective, while red wine is hypothesized to offer benefit in part due to the proangiogenic and antioxidant properties of polyphenols. We investigated the cardiovascular effects of both red wine and vodka in a swine model of endothelial dysfunction.
methodsTwenty-seven male Yorkshire swine fed a high-fat/cholesterol diet were divided into three groups and received either no alcohol (Control), red wine, or vodka. After 7 wk, myocardial perfusion was measured, and ventricular tissue was analyzed for microvascular reactivity and immunohistochemical studies.
resultsThere were no differences in myocardial perfusion, in arteriolar or capillary density, or in VEGF expression among groups. Total protein oxidation as well as expression of superoxide dismutase-1 and -2 and NADPH oxidase was decreased in both treatment groups compared to controls. Endothelium-dependent microvessel relaxation, however, was significantly improved only in the red wine-supplemented group.
conclusionsSupplementation with both red wine and vodka decreased oxidative stress by several measures, implicating the effects of ethanol in reducing oxidative stress in the myocardium. However, it was only in the red wine-supplemented group that an improvement in microvessel function was observed. This suggests that a component of red wine, independent of ethanol, possibly a polyphenol such as resveratrol, may confer cardioprotection by normalizing endothelial dysfunction induced by an atherogenic diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.