ReviewJournal of gastroenterology2012
Why dyspepsia can occur without organic disease: pathogenesis and management of functional dyspepsia.
Review in Journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Association of genetic variants in GNβ3 with functional dyspepsia: a meta-analysis.Digestive diseases and sciences · 2014Pooled it
- Comparison of the Effects of Govarcin Herbal Capsule and Metoclopramide for Alleviating Gastrointestinal Symptoms in Patients with Functional Dyspepsia: A Randomized Double-blind Clinical Trial.Reviews on recent clinical trials · 2024Trial
- Article
- Adverse Childhood Experiences Are Associated With an Increased Risk of Dyspepsia in Patients Undergoing Upper Endoscopy.Gastro hep advances · 2025Article
- Comprehensive Treatment of Functional Dyspepsia Using Traditional Chinese Medicine: A Review Based on Pathophysiological Perspectives.Drug design, development and therapy · 2025Review
- Factors Predicting Effectiveness of Eradication Therapy forLife (Basel, Switzerland) · 2024Article
- Efficacy and safety of the herbal formulaFrontiers in pharmacology · 2023Article
- Aqueous Extract ofFoods (Basel, Switzerland) · 2022Article
- Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia.Journal of neurogastroenterology and motility · 2022Article
- Frequency and risk factors of non-alcoholic fatty liver disease inSAGE open medicine · 2021Article
- Effect ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center.Journal of gastroenterology · 2019Review
- Higher frequency of upper gastrointestinal symptoms in healthy young Japanese females compared to males and older generations.Esophagus : official journal of the Japan Esophageal Society · 2018Article
- Ethnic/racial differences in gastrointestinal symptoms and diagnosis associated with the risk ofClinical and experimental gastroenterology · 2018Article
- Genetic variants of immune-related genes IL17F and IL10 are associated with functional dyspepsia: A case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- Impaired Interoception in a Preclinical Model of Functional Dyspepsia.Digestive diseases and sciences · 2017Article
- Article
- Upper Gastrointestinal Symptoms Are More Frequent in Female than Male Young Healthy Japanese Volunteers as Evaluated by Questionnaire.Journal of neurogastroenterology and motility · 2016Article
- Small Intestinal Bacterial Overgrowth in Patients with Refractory Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2016Article
- Effect of Aurantii Fructus Immaturus Flavonoid on the Contraction of Isolated Gastric Smooth Muscle Strips in Rats.Evidence-based complementary and alternative medicine : eCAM · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional dyspepsia (FD), one of the most common conditions in medicine, is a gastrointestinal disorder in which the patient suffers from chronic dyspeptic symptoms such as epigastralgia and a heavy feeling in the stomach despite the absence of organic disease. Elucidating the pathogenesis of FD means answering the question, "Why do symptoms occur?" The factors contributing to symptom manifestation in FD probably should be divided into 3 categories: (1) physiological abnormalities that directly induce symptoms, (2) factors that modify those physiological abnormalities, and (3) factors that govern abnormal responses to stress. The symptoms of FD are directly caused by two major physiological abnormalities-abnormal gastric motility and visceral hypersensitivity-occurring in patients who have acquired excessive responsiveness to stress as a result of the environment during early life, genetic abnormalities, residual inflammation after gastrointestinal infections, or other causes, with the process modified by factors including psychophysiological abnormalities, abnormal secretion of gastric acid, Helicobacter pylori infection, diet, and lifestyle. If the basis of this model of FD pathogenesis is excessive responsiveness of gastrointestinal function to stress and external stimuli, psychosomatic approaches to alter stress perception could be important treatment options. However, in the primary care setting, the treatment of FD has focused on local gastric factors, including abnormal gastric acid secretion, abnormal gastric motility, and H. pylori infection. Acid secretion inhibitors and prokinetics have been commonly used, and H. pylori eradication therapy has been carried out, but the effectiveness of drug therapy has been limited.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.