ArticlePloS one2012
Hypoglycemia in non-diabetic in-patients: clinical or criminal?
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- Improving diagnostic accuracy of 72-hour supervised fasting test for hypoglycemia evaluation: A quality improvement project.World journal of methodology · 2026Review
- Rare Causes of Hypoglycemia-Lessons from Case Reports.JCEM case reports · 2025Article
- Evaluation of Asymptomatic Fasting Hypoglycemia in Outpatients Without Diabetes.Journal of the American Board of Family Medicine : JABFM · 2025Article
- Diagnosis and Surgical Management of Pancreatic Insulinoma in a Non-Diabetic Patient: A Case Report.Reports (MDPI) · 2025Article
- Article
- The Effect of 50% Dextrose on Serum Glucose Levels in Adult Hypoglycemic Patients: A Prospective Observational Study.Cureus · 2025Article
- Hypoglycemia and hospital mortality in critically ill patients.Scientific reports · 2025Article
- Hypoglycemia in non-diabetic in-patients at a teaching referral hospital in Iran.Journal of diabetes and metabolic disorders · 2024Article
- Clopidogrel-induced non-diabetic hypoglycemia reported from Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: a case report.Journal of medical case reports · 2023Article
- The Role of Platelets in Hypoglycemia-Induced Cardiovascular Disease: A Review of the Literature.Biomolecules · 2023Review
- Symptomatic hypoglycemia in a nondiabetic adult female recovering from mild COVID-19 infection: A case report.Clinical case reports · 2022Article
- Prevalence and characteristics of factitious hypoglycaemia in non-diabetic patients in a department of endocrinology.Endocrinology, diabetes & metabolism · 2022Article
- Frequency of Adrenal Insufficiency in Patients With Hypoglycemia in an Emergency Department: A Cross-sectional Study.Journal of the Endocrine Society · 2022Article
- Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2022Article
- Fasting biochemical hypoglycemia and related-factors in non-diabetic population: Kanagawa Investigation of Total Check-up Data from National Database-8.World journal of diabetes · 2021Article
- Preparation for endoscopic examinations in patients with diabetes and hypoglycaemia.Przeglad gastroenterologiczny · 2021Review
- Non- pancreatic neuroendocrine tumour presenting with hypoglycemia in an elderly patient.African health sciences · 2020Article
- Electronic Measurement of a Clinical Quality Measure for Inpatient Hypoglycemic Events: A Multicenter Validation Study.Medical care · 2020Article
- Effects and mechanisms of glucose-insulin-potassium on post-procedural myocardial injury after percutaneous coronary intervention.Journal of geriatric cardiology : JGC · 2020Article
- A Single Episode of Hypoglycemia as a Possible Early Warning Sign of Adrenal Insufficiency.Therapeutics and clinical risk management · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimWe wished to establish the frequency of unexpected hypoglycemia observed in non diabetic patients outside the intensive care unit and to determine if they have a plausible clinical explanation.
methodsWe analysed data for 2010 from three distinct sources to identify non diabetic hypoglycaemic patients: bedside and laboratory blood glucose measurements; medication records for those treatments (high-strength glucose solution and glucagon) commonly given to reverse hypoglycemia; and diagnostic codes for hypoglycemia. We excluded from the denominator admissions of patients with a diagnosis of diabetes or prescribed diabetic medication. Case notes of patients identified were reviewed. We used capture-recapture methods to establish the likely frequency of hypoglycemia in non-diabetic in-patients outside intensive care unit at different cut-off points for hypoglycemia. We also recorded co-morbidities that might have given rise to hypoglycemia.
resultsAmong the 37,898 admissions, the triggers identified 71 hypoglycaemic episodes at a cut-off of 3.3 mmol/l. Estimated frequency at 3.3 mmol/l was 50(CI 33-93), at 3.0 mmol/l, 36(CI 24-64), at 2.7 mmol/l, 13(CI 11-19), at 2.5 mmol/l, 11(CI 9-15) and at 2.2 mmol/l, 8(CI 7-11) per 10,000 admissions. Admissions of patients aged above 65 years were approximately 50% more likely to have an episode of hypoglycemia. Most were associated with important co-morbidities.
conclusionSignificant non-diabetic hypoglycemia in hospital in-patients (at or below 2.7 mmol/l) outside critical care is rare. It is sufficiently rare for occurrences to merit case-note review and diagnostic blood tests, unless an obvious explanation is found.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.