ArticleMetabolism: clinical and experimental2012
Daidzein-metabolizing phenotypes in relation to bone density and body composition among premenopausal women in the United States.
Article in Metabolism: clinical and experimental, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The association of dietary polyphenols with obesity: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.International journal of molecular sciences · 2018Pooled it
- Cardiovascular disease risk factors in women with O-desmethylangolensin producing and non-producing gut microbial metabotypes: an observational study.BMC cardiovascular disorders · 2026Observational
- Gut Dysbiosis in Animals Due to Environmental Chemical Exposures.Frontiers in cellular and infection microbiology · 2017Review
- The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids.The American journal of clinical nutrition · 2017Review
- Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein.European journal of clinical nutrition · 2014Article
- Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.PloS one · 2014Article
- Isoflavone metabolism and bone-sparing effects of daidzein-metabolites.Journal of clinical biochemistry and nutrition · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundBone density has been suggested as a marker of cumulative hormone exposure. Small studies also suggest that patterns of daidzein metabolism may be related to hormone concentrations. To our knowledge, no studies in premenopausal women have compared bone density by daidzein-metabolizing phenotypes in the absence of a soy intervention.
objectiveThe objective was to evaluate the relationship between daidzein-metabolizing phenotypes [equol and O-desmethylangolensin (ODMA) production] and bone density and body composition in premenopausal women in the United States. MATERIALS/
methodsTwo hundred and three women attended a clinic visit during which their bone density and body composition were measured by DXA, and 200 (99 %) provided a urine sample following a 3-day soy challenge. Samples were analyzed for isoflavones to determine daidzein-metabolizing phenotypes.
resultsIn adjusted analyses, there were no differences in hip, spine, femoral neck, or head bone mineral density (BMD) or body composition between producers and non-producers of either equol or ODMA (P > .05).
conclusionsIn this population of low-soy consuming premenopausal women, there were no associations between daidzein-metabolizing phenotypes and hip, spine, femoral neck, or head BMD or body composition, suggesting that these phenotypes per se do not influence premenopausal bone density or body composition.
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