ArticleBMC evolutionary biology2012
Adaptive evolution of Toll-like receptor 5 in domesticated mammals.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Host control and the evolution of cooperation in host microbiomes.Nature communications · 2022Article
- MicroRNAs: Important Regulatory Molecules in Acute Lung Injury/Acute Respiratory Distress Syndrome.International journal of molecular sciences · 2022Review
- Characterisation and functional analysis of canine TLR5.Innate immunity · 2020Article
- Analysis of substitution rates showed that TLR5 is evolving at different rates among mammalian groups.BMC evolutionary biology · 2019Article
- Functional expression of TLR5 of different vertebrate species and diversification in intestinal pathogen recognition.Scientific reports · 2018Article
- Genomic organization and adaptive evolution of IGHC genes in marine mammals.Molecular immunology · 2018Article
- Host species adaptation of TLR5 signalling and flagellin recognition.Scientific reports · 2017Article
- The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.Science (New York, N.Y.) · 2017Article
- Evolution of toll-like receptors in the context of terrestrial ungulates and cetaceans diversification.BMC evolutionary biology · 2017Article
- Adaptive evolution of virus-sensing toll-like receptor 8 in bats.Immunogenetics · 2016Article
- LMAP: Lightweight Multigene Analyses in PAML.BMC bioinformatics · 2016Article
- Phenotypic and functional analysis of monocyte populations in cattle peripheral blood identifies a subset with high endocytic and allogeneic T-cell stimulatory capacity.Veterinary research · 2015Article
- Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagella.Veterinary research · 2015Article
- Protein evolution of Toll-like receptors 4, 5 and 7 within Galloanserae birds.Genetics, selection, evolution : GSE · 2014Article
- Functional characterisation of bovine TLR5 indicates species-specific recognition of flagellin.Veterinary immunology and immunopathology · 2014Article
- Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE).BMC evolutionary biology · 2013Article
- Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection.BMC evolutionary biology · 2013Article
- The molecular pathways underlying host resistance and tolerance to pathogens.Frontiers in genetics · 2012Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection. To determine if this is the case, we examined the extent of adaptive evolution in the TLR5 gene in both individual species and defined clades of the mammalia.
resultsIn support of previous studies, we find evidence of adaptive evolution of mammalian TLR5. However, we also show that TLR5 genes of domestic livestock have a concentration of single nucleotide polymorphisms suggesting a specific signature of adaptation. Using codon models of evolution we have identified a concentration of rapidly evolving codons within the TLR5 extracellular domain a site of interaction between host and the bacterial surface protein flagellin.
conclusionsThe results suggest that interactions between pathogen and host may be driving adaptive change in TLR5 by competition between species. In support of this, we have identified single nucleotide polymorphisms (SNP) in sheep and cattle TLR5 genes that are co-localised and co-incident with the predicted adaptive codons suggesting that adaptation in this region of the TLR5 gene is on-going in domestic species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.