ArticleAnesthesiology2012
miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
Article in Anesthesiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Role of an imbalanced miRNAs axis in pathogenesis of psoriasis: novel perspectives based on review of the literature.Oncotarget · 2017Pooled it
- miRNA-146-a, miRNA-21, miRNA-143, miRNA-29-b and miRNA-223 as Potential Biomarkers for Atopic Dermatitis.Clinics and practice · 2025Article
- miRNA-22 UpregulatesOxidative medicine and cellular longevity · 2022Article
- Advances With Non-coding RNAs in Neuropathic Pain.Frontiers in neuroscience · 2021Review
- Optimizing Perioperative Use of Opioids: A Multimodal Approach.Current anesthesiology reports · 2020Article
- Role of Micro-RNA for Pain After Surgery: Narrative Review of Animal and Human Studies.Anesthesia and analgesia · 2020Review
- MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.Journal of neuroinflammation · 2018Article
- MicroRNA-182 Alleviates Neuropathic Pain by Regulating Nav1.7 Following Spared Nerve Injury in Rats.Scientific reports · 2018Article
- miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis.Journal of neuroinflammation · 2018Article
- miR-365 targets β-arrestin 2 to reverse morphine tolerance in rats.Scientific reports · 2016Article
- miR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1.Scientific reports · 2016Article
- MicroRNA-Based Biomarkers in Pain.Advances in pharmacology (San Diego, Calif.) · 2016Review
- Computational functional genomics based analysis of pain-relevant micro-RNAs.Human genetics · 2015Article
- Identification of a novel substance P (SP)-neurokinin-1 receptor (NK-1R) microRNA-221-5p inflammatory network in human colonic epithelial cells.Cellular and molecular gastroenterology and hepatology · 2015Article
- Sex differences in a Murine Model of Complex Regional Pain Syndrome.Neurobiology of learning and memory · 2015Article
- Epigenetic regulation of persistent pain.Translational research : the journal of laboratory and clinical medicine · 2015Review
- Quantification of the differential expression levels of microRNA-203 in different degrees of diabetic foot.International journal of clinical and experimental pathology · 2015Article
- MicroRNA biology and pain.Progress in molecular biology and translational science · 2015Review
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAfter incision keratinocytes in the epidermis become activated to produce a range of pain-related mediators. microRNA 203 (miR-203) is known to be involved in keratinocyte growth, differentiation, and skin inflammation. We hypothesized that one or more of these mediators might be under the control of miR-203.
methodsThe expression of miR-203 and its target gene, phospholipase A2 activating protein (PLAA), were examined after hind paw incision in mice. We investigated the local effect of intraplantar PLAA peptide injection in normal mice and the effects of a selective secretory phospholipase A2 inhibitor (HK064) on PLAA or incision-induced mechanical allodynia. Last, we investigated the role of substance P signaling in regulating miR-203 and PLAA expression in vitro and in vivo.
resultsLevels of miR-203 were strongly down-regulated in keratinocytes after incision. Informatics-based approaches identified PLAA as a likely candidate for regulation by miR-203. PLAA caused mechanical allodynia and conditioned place aversion but not thermal sensitization. HK064 reduced mechanical allodynia after incision and after intraplantar injection of PLAA. Using preprotachykinin gene knockout mice or with neurokinin-1 selective antagonist LY303870 treatment, we observed that substance P-mediated signaling was also required for miR-203 and PLAA regulation after incision. Finally, using the rat epidermal keratinocyte cell line, we observed that a miR-203 mimic molecule could block the substance P-induced increase in PLAA expression observed under control conditions.
conclusionsmiR-203 may regulate expression of the novel nociceptive mediator PLAA after incision. Furthermore, the regulation of miR-203 and PLAA levels is reliant upon intact substance P signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.