Trial reportPloS one2012
Hemoglobin A1c levels and aortic arterial stiffness: the Cardiometabolic Risk in Chinese (CRC) study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study.PloS one · 2017Trial
- Neck circumference and early stage atherosclerosis: the cardiometabolic risk in Chinese (CRC) study.Cardiovascular diabetology · 2014Trial
- Linking glucose metabolism to arterial stiffness and blood pressure in non-diabetic adults: the mediating role of FGF21.Frontiers in cardiovascular medicine · 2026Article
- Role of Advanced Glycation End Products in Mediating Glycated Haemoglobin and Pulse Wave Velocity in Healthy Adults.Biomedicines · 2025Article
- Associations of blood biomarkers with arterial stiffness in patients with diabetes mellitus: A population-based study.Journal of diabetes · 2023Article
- Arterial Stiffness and HbA1c: Association Mediated by Insulin Resistance in Hispanic Adults.International journal of environmental research and public health · 2022Article
- Glycated Hemoglobin and Risk of Arterial Stiffness in a Chinese Han Population: A Longitudinal Study.Frontiers in endocrinology · 2022Article
- Cardio-Ankle Vascular Index in the Persons with Pre-Diabetes and Diabetes Mellitus in the Population Sample of the Russian Federation.Diagnostics (Basel, Switzerland) · 2021Article
- Arterial stiffness in type 2 diabetes: determinants and indication of a discriminative value.Clinics (Sao Paulo, Brazil) · 2021Article
- Evaluation of the associations of body height with blood pressure and early-stage atherosclerosis in Chinese adults.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Prognostic value of arterial stiffness measurements in cardiovascular disease, diabetes, and its complications: The potential role of sodium-glucose co-transporter-2 inhibitors.Journal of clinical hypertension (Greenwich, Conn.) · 2020Review
- Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels.Journal of clinical medicine · 2019Article
- Article
- Prediabetes and Diabetes Are Associated With Arterial Stiffness in Older Adults: The ARIC Study.American journal of hypertension · 2016Article
- Increased central arterial stiffness and altered cerebrovascular haemodynamic properties in South Asian older adults.Journal of human hypertension · 2016Article
- Independent association between glycated hemoglobin and arterial stiffness in healthy men.Journal of diabetes investigation · 2016Article
- Diabetes Mellitus, Arterial Wall, and Cardiovascular Risk Assessment.International journal of environmental research and public health · 2016Review
- Correlates of Segmental Pulse Wave Velocity in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study.American journal of hypertension · 2016Article
- Neck circumference and prehypertension: the cardiometabolic risk in Chinese study.Journal of hypertension · 2015Article
- Glycemic control and arterial stiffness in a Brazilian rural population: Baependi Heart Study.Diabetology & metabolic syndrome · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe American Diabetes Association (ADA) recently published new clinical guidelines in which hemoglobin A1c (HbA1c) was recommended as a diagnostic test for diabetes. The present study was to investigate the association between HbA1c and cardiovascular risk, and compare the associations with fasting glucose and 2-hour oral glucose tolerance test (2 h OGTT). RESEARCH DESIGN AND
methodsThe study samples are from a community-based health examination survey in central China. Carotid-to-femoral pulse wave velocity (cfPWV) and HbA1c were measured in 5,098 men and women.
resultsAfter adjustment for age, sex, and BMI, the levels of HbA1c were significantly associated with an increasing trend of cfPWV in a dose-dependent fashion (P for trend <0.0001). The associations remained significant after further adjustment for blood pressure, heart rate, and lipids (P = 0.004), and the difference in cfPWV between the highest and the lowest quintiles of HbA1c was 0.31 m/s. Fasting glucose and 2 h OGTT were not associated with cfPWV in the multivariate analyses. HbA1c showed additive effects with fasting glucose or 2 h OGTT on cfPWV. In addition, age and blood pressure significantly modified the associations between HbA1c and cfPWV (P for interactions <0.0001 for age; and = 0.019 for blood pressure). The associations were stronger in subjects who were older (≥60 y; P for trend = 0.004) and had higher blood pressure (≥120 [systolic blood pressure]/80 mmHg [diastolic blood pressure]; P for trend = 0.028) than those who were younger and had lower blood pressure (P for trend >0.05).
conclusionsHbA1c was related to high cfPWV, independent of conventional cardiovascular risk factors. Senior age and high blood pressure might amplify the adverse effects of HbA1c on cardiovascular risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.