ReviewJournal of clinical gastroenterology2012
The association of primary hyperparathyroidism with pancreatitis.
Review in Journal of clinical gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Endocrine surgery during and after the COVID-19 epidemic: Expert guidelines from AFCE.Journal of visceral surgery · 2020Guideline
- Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.Journal of pediatric gastroenterology and nutrition · 2017Pooled it
- Recurrent Acute Pancreatitis Secondary to Untreated Hyperparathyroidism: A Case Report and Literature Review.Cureus · 2026Article
- Primary hyperparathyroidism-associated pancreatitis: poor prognosis, distinct serum calcium trajectories, and proactive therapeutic implications.Gastroenterology report · 2026Article
- Recurrent acute necrotizing pancreatitis secondary to hypercalcemic crisis in hyperparathyroidism: a case report.Journal of medical case reports · 2025Article
- An Often Missed Cause of Chronic Pancreatitis: A Case Report on the Rare Presentation of Primary Hyperparathyroidism.Clinical case reports · 2025Article
- Unmasking hidden culprits: The pivotal role of 4D CT in diagnosing parathyroid adenoma presenting as acute pancreatitis.Radiology case reports · 2025Article
- Recurrent acute pancreatitis and primary hyperparathyroidism in patients presenting to the emergency department: Diagnostic challenges.World journal of clinical cases · 2025Article
- Recurrent acute pancreatitis as an initial presentation of primary hyperparathyroidism in juvenile patient.World journal of clinical cases · 2025Article
- Article
- Acute pancreatitis and refractory hypercalcemia in the third trimester caused by parathyroid carcinoma.BMC pregnancy and childbirth · 2024Article
- Hyperparathyroidism with acute pancreatitis in elderly patient treated by radiofrequency ablation: A case report.Radiology case reports · 2024Article
- Article
- Variant Tyr 394Ser in theJournal of the Endocrine Society · 2023Article
- Article
- Effect of plant polysaccharides (Bioscience of microbiota, food and health · 2023Article
- Rare case of pancreatitis treated by minimally invasive parathyroidectomy.BMJ case reports · 2022Article
- Primary hyperparathyroidism presenting as acute pancreatitis: An institutional experience with review of the literature.World journal of gastrointestinal pharmacology and therapeutics · 2022Article
- Three pediatric patients with primary hyperparathyroidism caused by parathyroid adenoma.Annals of pediatric endocrinology & metabolism · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The association between primary hyperparathyroidism (PHPT) and acute or chronic pancreatitis is controversial. For this reason, we conducted a review of the literature over the past 30 years to explore the relationship between these 2 disorders. Ten retrospective studies each with >50 patients diagnosed with PHPT were identified. With the notable exception of 2 studies, the rate of pancreatitis among patients with PHPT was higher than that reported in general among hospitalized patients without PHPT. A higher serum calcium level may contribute to pancreatitis in these cases, along with additional genetic or environmental insults. Hypercalcemia may predispose the pancreatic acinar cell to abnormal, sustained calcium levels, lead to premature pancreatic protease activation, and pancreatitis. Although there was only short-term follow-up, most reports cited that definitive treatment of PHPT by parathyroidectomy led to the resolution of pancreatitis attacks. The published cohorts of patients with PHPT and pancreatitis are subject to bias, because serum calcium screening was not universally performed among all control nonpancreatitis patients to evaluate for PHPT. However, the pooled clinical and experimental data suggest an association between PHPT and pancreatitis and implicate hypercalcemia. For clinicians, it is important to recognize pancreatitis in patients with PHPT and, conversely, to consider PHPT by checking serum calcium levels in patients, who present with an unexplained pancreatitis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.