Evidence map›Paper›PMID 22901266›Full record

ReviewAnnals of the New York Academy of Sciences2012

Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function.

Hal E Broxmeyer

Open access · greenAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Expansion of human hematopoietic stem cells by inhibiting translation.bioRxiv : the preprint server for biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Hal E BroxmeyerDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana.
Indiana University School of Medicine

Funding

BASIC SCIENCE STUDIES ON GENE THERAPY OF BLOOD DISEASEST32HL007910 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Roland W. Herzog, Reuben Kapur · 1999 to 2026
$7.6M
REGULATION OF HEMATOPOIETIC CELL PRODUCTIONT32DK007519 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1986 to 2020
$7.1M
MECHANISMS OF SYNERGISTIC REGULATION OF STEM/PROGENITORSR01HL056416 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI BROXMEYER, HAL E. · 1996 to 2017
$6.0M
Cytokine Enhancement of Myeloid Progenitor Cell SurvivalR01HL067384 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI BROXMEYER, HAL E. · 2001 to 2014
$4.6M
Regulating hematopoietic stem cells and hematopoiesis for clinical efficacyP30DK090948 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., SROUR, EDWARD F · 2010 to 2014
$3.7M
Enhancing Engraftment of Cord Blood by CD26 InhibitionR01HL112669 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., FARAG, SHERIF S · 2012 to 2016
$3.6M
NHLBI NIH HHS R01 HL056416NHLBI NIH HHS R01 HL067384NHLBI NIH HHS R01 HL112669NHLBI NIH HHS R01 HL67384NHLBI NIH HHS T32 HL007910NHLBI NIH HHS T32 HL07910NIDDK NIH HHS P01 DK090948NIDDK NIH HHS P30 DK090948NIDDK NIH HHS T32 DK007519NIDDK NIH HHS T32 DK07519
6 · The paper itself

Abstract

Cord blood (CB) transplantation has been used over the last 24 years to treat patients with malignant and nonmalignant disorders. CB has its advantages and disadvantages compared with other sources of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) for transplantation. More knowledge of the cytokines and intracellular signaling molecules regulating HSCs and HPCs could be used to modulate these regulators for clinical benefit. This review provides information about the general field of CB transplantation and about studies from the author's laboratory that focus on regulation of HSCs and HPCs by CD26/DPPIV, SDF-1/CXCL12, the Rheb2-mTOR pathway, SIRT1, DEK, cyclin-dependent kinase inhibitors, and cytokines/growth factors. Cryopreservation of CB HSCs and HPCs is also briefly discussed.

Indexed as

AnimalsChemokine CXCL12Cord Blood Stem Cell TransplantationCyclin-Dependent Kinase Inhibitor ProteinsCytokinesDipeptidyl Peptidase 4Graft Enhancement, ImmunologicHematopoiesisHematopoietic Stem CellsHumansIntracellular Signaling Peptides and ProteinsSignal TransductionSirtuin 1TOR Serine-Threonine KinasesChemokine CXCL12Cyclin-Dependent Kinase Inhibitor ProteinsCytokinesDipeptidyl Peptidase 4Intracellular Signaling Peptides and ProteinsSirtuin 1TOR Serine-Threonine Kinases

Identifiers

PMID22901266
PMCPMC3428743
OpenAlexW1944600811

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.