ArticlePloS one2012
Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 78 citations in OpenAlex.
- From Hair to the Brain: The Short-Term Therapeutic Potential of Human Hair Follicle-Derived Stem Cells and Their Conditioned Medium in a Rat Model of Stroke.Molecular neurobiology · 2023Article
- Enriched Environment and Exercise Enhance Stem Cell Therapy for Stroke, Parkinson's Disease, and Huntington's Disease.Frontiers in cell and developmental biology · 2022Review
- Human amniotic fluid stem cells can improve cerebral vascular remodelling and neurological function after focal cerebral ischaemia in diabetic rats.Journal of cellular and molecular medicine · 2021Article
- Combination of Stem Cells and Rehabilitation Therapies for Ischemic Stroke.Biomolecules · 2021Review
- The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke.Neural regeneration research · 2021Article
- Protective effects of mesenchymal stem cells on ischemic brain injury: therapeutic perspectives of regenerative medicine.Cell and tissue banking · 2021Review
- Human umbilical cord blood cells rescued traumatic brain injury-induced cardiac and neurological deficits.Annals of translational medicine · 2020Article
- Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke.Brain hemorrhages · 2020Article
- In Utero Amniotic Fluid Stem Cell Therapy Protects Against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion.Stem cells translational medicine · 2019Article
- Regulatory T-cells within bone marrow-derived stem cells actively confer immunomodulatory and neuroprotective effects against stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Drug-like delivery methods of stem cells as biologics for stroke.Expert opinion on drug delivery · 2019Review
- Stem cell therapy for neurological disorders: A focus on aging.Neurobiology of disease · 2019Review
- Endothelial Progenitor Cells Modulate Inflammation-Associated Stroke Vasculome.Stem cell reviews and reports · 2019Article
- Placenta-Derived Cells for Acute Brain Injury.Cell transplantation · 2018Review
- Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms.Progress in neurobiology · 2017Review
- A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Article
- NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats.Journal of cellular physiology · 2017Article
- Intravenously Transplanted Human Bone Marrow Endothelial Progenitor Cells Engraft Within Brain Capillaries, Preserve Mitochondrial Morphology, and Display Pinocytotic Activity Toward Blood-Brain Barrier Repair in Ischemic Stroke Rats.Stem cells (Dayton, Ohio) · 2017Article
- Stem Cell Recipes of Bone Marrow and Fish: Just What the Stroke Doctors Ordered.Stem cell reviews and reports · 2017Review
- Bladder Transplantation of Amniotic Fluid Stem Cell may Ameliorate Bladder Dysfunction After Focal Cerebral Ischemia in Rat.Stem cells translational medicine · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently reported isolation of viable rat amniotic fluid-derived stem (AFS) cells [1]. Here, we tested the therapeutic benefits of AFS cells in a rodent model of ischemic stroke. Adult male Sprague-Dawley rats received a 60-minute middle cerebral artery occlusion (MCAo). Thirty-five days later, animals exhibiting significant motor deficits received intravenous transplants of rat AFS cells or vehicle. At days 60-63 post-MCAo, significant recovery of motor and cognitive function was seen in stroke animals transplanted with AFS cells compared to vehicle-infused stroke animals. Infarct volume, as revealed by hematoxylin and eosin (H&E) staining, was significantly reduced, coupled with significant increments in the cell proliferation marker, Ki67, and the neuronal marker, MAP2, in the dentate gyrus (DG) [2] and the subventricular zone (SVZ) of AFS cell-transplanted stroke animals compared to vehicle-infused stroke animals. A significantly higher number of double-labeled Ki67/MAP2-positive cells and a similar trend towards increased Ki67/MAP2 double-labeling were observed in the DG and SVZ of AFS cell-transplanted stroke animals, respectively, compared to vehicle-infused stroke animals. This study reports the therapeutic potential of AFS cell transplantation in stroke animals, possibly via enhancement of endogenous repair mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.