ArticlePloS one2012
Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Natural compounds as regulators of miRNAs: exploring a new avenue for treating brain cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Luteolin for neurodegenerative diseases: a review.Pharmacological reports : PR · 2024Review
- The Neuroprotective Effects of Flavonoid Fisetin against Corticosterone-Induced Cell Death through Modulation of ERK, p38, and PI3K/Akt/FOXO3a-Dependent Pathways in PC12 Cells.Pharmaceutics · 2023Article
- Article
- Dietary Flavonoids and Adult Neurogenesis: Potential Implications for Brain Aging.Current neuropharmacology · 2023Review
- Luteolin Induced Hippocampal Neuronal Pyroptosis Inhibition by Regulation of miR-124-3p/TNF-Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Extracellular vesicles synchronize cellular phenotypes of differentiating cells.Journal of extracellular vesicles · 2021Article
- Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats.Pregnancy hypertension · 2021Article
- MicroRNA-135a-5p Promotes the Functional Recovery of Spinal Cord Injury by Targeting SP1 and ROCK.Molecular therapy. Nucleic acids · 2020Article
- Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.Neural regeneration research · 2019Article
- Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats.Medical science monitor basic research · 2018Article
- Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein.International journal of molecular sciences · 2018Article
- An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway.Scientific reports · 2017Article
- Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway.Oncotarget · 2017Article
- Advances in Roles of miR-132 in the Nervous System.Frontiers in pharmacology · 2017Review
- miR-124 promotes the neuronal differentiation of mouse inner ear neural stem cells.International journal of molecular medicine · 2016Article
- Role of dietary phenols in mitigating microglia-mediated neuroinflammation.Neuromolecular medicine · 2016Review
- Luteolin inhibited proliferation and induced apoptosis of prostate cancer cells through miR-301.OncoTargets and therapy · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Luteolin (3',4',5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to exert neurotrophic properties that are associated with its capacity to promote neuronal survival and neurite outgrowth. In this study, we report for the first time that luteolin induces the persistent expression of microRNA-132 (miR-132) in PC12 cells. The correlation between miR-132 knockdown and a decrease in luteolin-mediated neurite outgrowth may indicate a mechanistic link by which miR-132 functions as a mediator for neuritogenesis. Furthermore, we find that luteolin led to the phosphorylation and activation of cAMP response element binding protein (CREB), which is associated with the up-regulation of miR-132 and neurite outgrowth. Moreover, luteolin-induced CREB activation, miR-132 expression and neurite outgrowth were inhibited by adenylate cyclase, protein kinase A (PKA) and MAPK/ERK kinase 1/2 (MEK1/2) inhibitors but not by protein kinase C (PKC) or calcium/calmodulin-dependent protein kinase II (CaMK II) inhibitors. Consistently, we find that luteolin treatment increases ERK phosphorylation and PKA activity in PC12 cells. These results show that luteolin induces the up-regulation of miR-132, which serves as an important regulator for neurotrophic actions, mainly acting through the activation of cAMP/PKA- and ERK-dependent CREB signaling pathways in PC12 cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.