ArticlePloS one2012
The association between prenatal psychosocial stress and blood pressure in the child at age 5-7 years.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes.International journal of obesity (2005) · 2020Pooled it
- Acute maternal stress in pregnancy and cardiovascular risk factors in adolescent offspring: a birth-cohort study.International journal of epidemiology · 2026Article
- Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.Developmental psychology · 2024Review
- Pediatric Hypertension: A Condition That Matters.Children (Basel, Switzerland) · 2024Review
- Blood Pressure in Children in the 21st Century: What Do We Know and Where Do We Go From Here?Hypertension (Dallas, Tex. : 1979) · 2023Review
- Vascular Effects, Potential Pathways and Mediators of Fetal Exposure to Alcohol and Cigarette Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2023Review
- Epigenetic modifications and fetal programming: Molecular mechanisms to control hypertension inheritance.Biochemical pharmacology · 2023Review
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- In utero exposure to the Great Chinese Famine and risk of intracerebral hemorrhage in midlife.Neurology · 2020Article
- Exposure to Parental Depression in Adolescence and Risk for Metabolic Syndrome in Adulthood.Child development · 2019Article
- Effect of excessive infant crying on resting BP, HRV and cardiac autonomic control in childhood.PloS one · 2018Observational
- Family and Social Context Contributes to the Interplay of Economic Insecurity, Food Insecurity, and Health.Annals of anthropological practice · 2017Article
- Blood pressure in young adulthood and residential greenness in the early-life environment of twins.Environmental health : a global access science source · 2017Article
- Evidence for Ancestral Programming of Resilience in a Two-Hit Stress Model.Frontiers in behavioral neuroscience · 2017Article
- Prenatal maternal depression is associated with offspring inflammation at 25 years: a prospective longitudinal cohort study.Translational psychiatry · 2016Article
- Effect of maternal job strain during pregnancy on infant neurodevelopment by gender at 6 and 12 months: Mothers and Children's Environmental Health (MOCEH) study.Annals of occupational and environmental medicine · 2015Article
- The association of maternal prenatal psychosocial stress with vascular function in the child at age 10-11 years: findings from the Avon longitudinal study of parents and children.European journal of preventive cardiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrenatal maternal stress could have permanent effects on the offspring's tissue structure and function, which may predispose to cardiovascular diseases. We investigated whether maternal psychosocial stress is a prenatal factor affecting the blood pressure (BP) of offspring. STUDY
designIn the Amsterdam Born Children and their Development (ABCD) study, around gestational week 16, depressive symptoms, state-anxiety, pregnancy-related anxiety, parenting daily hassles and job strain were recorded by questionnaire. A cumulative stress score was also calculated (based on 80(th) percentiles). Systolic and diastolic BP and mean arterial pressure (MAP) were measured in the offspring at age 5-7 years. Inclusion criteria were: no use of antihypertensive medication during pregnancy; singleton birth; no reported cardiovascular problems in the child (N = 2968 included).
resultsAfter adjustment for confounders, the single stress scales were not associated with systolic and diastolic BP, MAP and hypertension (p>0.05). The presence of 3-4 psychosocial stressors prenatally (4%) was associated with 1.5 mmHg higher systolic and diastolic BP (p = 0.046; p = 0.04) and 1.5 mmHg higher MAP in the offspring (p = 0.02) compared to no stressors (46%). The presence of 3-4 stressors did not significantly increase the risk for hypertension (OR 1.8; 95% CI 0.93.4). Associations did not differ between sexes. Bonferroni correction for multiple testing rendered all associations non-significant.
conclusionsThe presence of multiple psychosocial stressors during pregnancy was associated with higher systolic and diastolic BP and MAP in the child at age 5-7. Further investigation of maternal prenatal stress may be valuable for later life cardiovascular health.
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