ReviewAmerican journal of physiology. Cell physiology2012
Systems biology in physiology: the vasopressin signaling network in kidney.
Review in American journal of physiology. Cell physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.British journal of pharmacology · 2025Review
- The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.British journal of pharmacology · 2023Article
- CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase.American journal of physiology. Renal physiology · 2020Article
- Single-tubule RNA-Seq uncovers signaling mechanisms that defend against hyponatremia in SIADH.Kidney international · 2018Article
- Systems-level analysis reveals selective regulation of Aqp2 gene expression by vasopressin.Scientific reports · 2016Article
- BIG: a large-scale data integration tool for renal physiology.American journal of physiology. Renal physiology · 2016Article
- Comprehensive database of human E3 ubiquitin ligases: application to aquaporin-2 regulation.Physiological genomics · 2016Article
- Proteomic profiling of nuclear fractions from native renal inner medullary collecting duct cells.Physiological genomics · 2016Article
- Deep proteomic profiling of vasopressin-sensitive collecting duct cells. II. Bioinformatic analysis of vasopressin signaling.American journal of physiology. Cell physiology · 2015Article
- High Water Intake and Progression of Chronic Kidney Diseases.Electrolyte & blood pressure : E & BP · 2015Review
- A Minireview on Vasopressin-regulated Aquaporin-2 in Kidney Collecting Duct Cells.Electrolyte & blood pressure : E & BP · 2015Review
- A knowledge base of vasopressin actions in the kidney.American journal of physiology. Renal physiology · 2014Article
- Letter to the editor: "Systems biology versus reductionism in cell physiology".American journal of physiology. Cell physiology · 2014Article
- Integrated Design of Antibodies for Systems Biology UsingJournal of proteomics & bioinformatics · 2014Article
- The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.British journal of pharmacology · 2013Article
- Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis.Kidney research and clinical practice · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Over the past 80 years, physiological research has moved progressively in a reductionist direction, providing mechanistic information on a smaller and smaller scale. This trend has culminated in the present focus on "molecular physiology," which deals with the function of single molecules responsible for cellular function. There is a need to assemble the information from the molecular level into models that explain physiological function at cellular, tissue, organ, and whole organism levels. Such integration is the major focus of an approach called "systems biology." The genome sequencing projects provide a basis for a new kind of systems biology called "data-rich" systems biology that is based on large-scale data acquisition methods including protein mass spectrometry, DNA microarrays, and deep sequencing of nucleic acids. These techniques allow investigators to measure thousands of variables simultaneously in response to an external stimulus. My laboratory is applying such an approach to the question: "How does the peptide hormone vasopressin regulate water permeability in the renal collecting duct?" We are using protein mass spectrometry to identify and quantify the phosphoproteome of collecting duct cells. The response to vasopressin, presented in the form of a network model, includes a general downregulation of proline-directed kinases (MAP kinases and cyclin-dependent kinases) and upregulation of basophilic kinases (ACG kinases and calmodulin-dependent kinases). Further progress depends on characterization and localization of candidate protein kinases in these families. The ultimate goal is to use multivariate statistical techniques and differential equations to obtain predictive models describing vasopressin signaling in the renal collecting duct.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.