SynthesisBMC medical genetics2012
UMOD as a susceptibility gene for end-stage renal disease.
Synthesis in BMC medical genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide association study of kidney function decline in individuals of European descent.Kidney international · 2015Pooled it
- Common variants in Mendelian kidney disease genes and their association with renal function.Journal of the American Society of Nephrology : JASN · 2013Pooled it
- Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Bioinformatics analysis and identification of genes and pathways involved in patients with Wilms tumor.Translational cancer research · 2022Article
- Donor-Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms.Frontiers in immunology · 2022Review
- Serum uromodulin and decline of kidney function in older participants of the population-based KORA F4/FF4 study.Clinical kidney journal · 2021Article
- Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.Scientific reports · 2020Article
- Non-diabetic end-stage renal disease in Saudis associated with polymorphism of MYH9 gene but not UMOD gene.Medicine · 2020Observational
- Genome-Wide Study Updates in the International Genetics and Translational Research in Transplantation Network (iGeneTRAiN).Frontiers in genetics · 2019Review
- Apolipoprotein L1 and Chronic Kidney Disease Risk in Young Potential Living Kidney Donors.Annals of surgery · 2018Article
- Effect of UMOD genotype on long-term graft survival after kidney transplantation in patients treated with cyclosporine-based therapy.The pharmacogenomics journal · 2018Article
- Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.Physiological reports · 2018Article
- Serum uromodulin-a marker of kidney function and renal parenchymal integrity.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Urinary Uromodulin and Risk of Urinary Tract Infections: The Cardiovascular Health Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Article
- Development of next generation sequencing panel for UMOD and association with kidney disease.PloS one · 2017Article
- Article
- A single nucleotide polymorphism in the UMOD promoter is associated with end stage renal disease.BMC medical genetics · 2016Article
- The Effects of CYP2C19 genotype on the susceptibility for nephrosis in cardio-cerebral vascular disease treated by anticoagulation.Medicine · 2016Observational
- Insights into kidney diseases from genome-wide association studies.Nature reviews. Nephrology · 2016Review
- Tamm Horsfall Glycoprotein and Uromodulin: It Is All about the Tubules!Clinical journal of the American Society of Nephrology : CJASN · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent genetic association studies, common variants including rs12917707 in the UMOD locus have shown strong evidence of association with eGFR, prevalent and incident chronic kidney disease and uromodulin urinary concentration in general population cohorts. The association of rs12917707 with end-stage renal disease (ESRD) in a recent case-control study was only nominally significant.
methodsTo investigate whether rs12917707 associates with ESRD, graft failure (GF) and urinary uromodulin levels in an independent cohort, we genotyped 1142 ESRD patients receiving a renal transplantation and 1184 kidney donors as controls. After transplantation, 1066 renal transplant recipients were followed up for GF. Urinary uromodulin concentration was measured at median [IQR] 4.2 [2.2-6.1] yrs after kidney transplantation.
resultsThe rs12917707 minor allele showed association with lower risk of ESRD (OR 0.89 [0.76-1.03], p = 0.04) consistent in effect size and direction with the previous report (Böger et al, PLoS Genet 2011). Meta-analysis of these findings showed significant association of rs12917707 with ESRD (OR 0.91 [0.85-98], p = 0.008). In contrast, rs12917707 was not associated with incidence of GF. Urinary uromodulin concentration was lower in recipients-carriers of the donor rs12917707 minor allele as compared to non-carriers, again consistent with previous observations in general population cohorts.
conclusionsOur study thus corroborates earlier evidence and independently confirms the association between UMOD and ESRD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.