ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2012
Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic models in populations with heart failure: a systematic review and meta-analysis.Systematic reviews · 2026Pooled it
- Prognostic usefulness of planarJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- Machine learning-based risk model usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Molecular Imaging of the Heart.Comprehensive Physiology · 2019Review
- SPECT vs. PET in cardiac innervation imaging: clash of the titans.Clinical and translational imaging · 2018Review
- Age- and sex-dependent changes in sympathetic activity of the left ventricular apex assessed by 18F-DOPA PET imaging.PloS one · 2018Article
- Sympathetic nervous system, systolic heart failure, and central sleep apnea: Are we about to find the missing link?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Beta blocker dose and markers of sympathetic activation in heart failure patients: interrelationships and prognostic significance.ESC heart failure · 2017Article
- Neurocardiac imaging has a proven value in patient management.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Current Clinical Applications and Next Steps for Cardiac Innervation Imaging.Current cardiology reports · 2017Review
- Creation of mortality risk charts using 123I meta-iodobenzylguanidine heart-to-mediastinum ratio in patients with heart failure: 2- and 5-year risk models.European heart journal. Cardiovascular Imaging · 2016Article
- Cost-Effectiveness Analysis of Iodine-123 Meta-Iodobenzylguanidine Imaging for Screening Heart Failure Patients Eligible for an Implantable Cardioverter Defibrillator in the USA.Applied health economics and health policy · 2016Article
- I-123 MIBG Cardiac Imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Radionuclide imaging of cardiac sympathetic innervation in heart failure: unlocking untapped potential.Heart failure reviews · 2015Review
- A prediction model for 5-year cardiac mortality in patients with chronic heart failure using ¹²³I-metaiodobenzylguanidine imaging.European journal of nuclear medicine and molecular imaging · 2014Article
- The sympathetic nervous system and heart failure.Cardiology clinics · 2014Review
- Cardiac autonomic imaging with SPECT tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Review
- A key role for nuclear cardiac imaging in evaluating and managing patients with heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2012Article
- Nuclear cardiology: 2014 innovations and developments.Methodist DeBakey cardiovascular journalReview
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Seattle Heart Failure Model (SHFM) is a multivariable model that uses demographic and clinical markers to predict survival in patients with heart failure. Inappropriate activation of the sympathetic nervous system, which contributes to the progression of heart failure and increased mortality, can be assessed using iodine-123 meta-iodobenzylguanidine (MIBG) cardiac imaging. This study investigated the incremental value of MIBG cardiac imaging when added to the SHFM for prediction of all-cause mortality.
methodsSurvival data from 961 NYHA II-III subjects in the ADMIRE-HFX trial were included in this analysis. The predictive value of the SHFM alone and in combination with MIBG heart-to-mediastinum ratio (H/M) was compared for all-cause mortality (101 deaths during a median follow-up of 2 years).
resultsThe addition of H/M to the SHFM in a Cox model significantly improved risk prediction (P < .0001), with a greater utility in higher risk SHFM patients. The observed 2-year mortality in the highest-risk SHFM subjects (rounded SHFM score of 1) was 24%, but varied from 46% with H/M <1.2 to 0% with H/M >1.8. Net reclassification improvement was 22.7% (P < .001), with 14.9% of subjects who died reclassified into a higher risk category than suggested by SHFM score alone (P = .01) and 7.9% of subjects who survived reclassified into a lower risk category (P < .0001). The 2-year integrated discrimination improvement (+4.14%, P < .0001) and the 1-year area under the receiver-operator characteristic curve (+0.04, P = .026) both showed significant improvement for the combined model with H/M compared to the SHFM alone.
conclusionThe addition of MIBG imaging to the SHFM improves risk stratification, especially in higher risk patients. MIBG may have clinical utility in higher risk patients who are being considered for devices such as ICD, CRT-D, LVAD, and cardiac transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.