ArticleClinical journal of the American Society of Nephrology : CJASN2012
Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Pre-transplant and persistent post-transplant hyperparathyroidism and kidney transplant outcomes: a systematic review and meta-analysis.Clinical kidney journal · 2026Article
- Post-transplant metabolic dysregulation: Insights and implications for kidney graft survival.World journal of nephrology · 2026Review
- Parathyroidectomy timing for persistent hyperparathyroidism in kidney transplant candidates and recipients: from secondary to tertiary disease: a literature review.Gland surgery · 2026Review
- Pre-Transplant Hyperparathyroidism and Graft or Patient Outcomes After Kidney Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Non-Traditional Non-Immunological Risk Factors for Kidney Allograft Loss-Opinion.Journal of clinical medicine · 2023Article
- A roadmap to parathyroidectomy for kidney transplant candidates.Clinical kidney journal · 2022Review
- Alkaline Phosphatase: An Old Friend as Treatment Target for Cardiovascular and Mineral Bone Disorders in Chronic Kidney Disease.Nutrients · 2022Review
- Article
- Association between serum alkaline phosphatase and renal outcome in patients with type 2 diabetes mellitus.Renal failure · 2020Article
- Serum phosphate levels modify the impact of parathyroid hormone levels on renal outcomes in kidney transplant recipients.Scientific reports · 2020Observational
- Liver Function Enzymes are Potential Predictive Markers for Kidney Allograft Dysfunction.Advancements in journal of urology and nephrology · 2020Article
- [Waiting list management].Der Urologe. Ausg. A · 2020Review
- Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function.Renal failure · 2019Article
- Serum alkaline phosphatase and the risk of coronary heart disease, stroke and all-cause mortality: Tehran Lipid and Glucose Study.BMJ open · 2018Article
- Prognostic significance of pre-end-stage renal disease serum alkaline phosphatase for post-end-stage renal disease mortality in late-stage chronic kidney disease patients transitioning to dialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Mineral and Bone Disorders After Kidney Transplantation.Frontiers in medicine · 2018Review
- Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD.Nature reviews. Nephrology · 2017Review
- Predictive Score for Posttransplantation Outcomes.Transplantation · 2017Article
- Changes in bone mineral density following long-term simultaneous pancreas-kidney transplantation.Journal of bone and mineral metabolism · 2016Article
- Oxidative Stress as Estimated by Gamma-Glutamyl Transferase Levels Amplifies the Alkaline Phosphatase-Dependent Risk for Mortality in ESKD Patients on Dialysis.Oxidative medicine and cellular longevity · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND AND
objectivesMineral and bone disorders (MBDs) are common in long-term dialysis patients and are risk factors for unfavorable outcomes. The associations between pretransplant levels of MBD surrogates and outcomes after kidney transplantation are not clear. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from the Scientific Registry of Transplant Recipients up to June 2007 were linked to the 5-year (July 2001-June 2006) cohort of a large dialysis organization in the United States. All dialysis patients who received a kidney transplant during this period were identified and divided into groups according to increments of pretransplant MBD markers. Unadjusted and multivariate adjusted predictors of transplant outcomes were examined.
resultsThe 11,776 patients were aged 47 ± 14 years and 39% were women. Compared with recipients with pretransplant time-averaged serum alkaline phosphatase of 80-120 U/L, recipients with pretransplant serum alkaline phosphatase of 120-160 and ≥160 U/L had 49% and 64% higher graft failure censored all-cause mortality in multivariable adjusted models. There was no significant association between time-averaged serum alkaline phosphatase categories and risk of death censored graft failure, delayed graft function (DGF), or acute rejection (AR). Compared with recipients with pretransplant time-averaged serum parathyroid hormone (PTH) levels of 150-300 pg/ml, there was no significant association with graft censored death among recipients with pretransplant serum PTH ≥800 pg/ml. In addition, the risk of graft failure, DGF, and AR did not show any association with time-averaged serum intact PTH level. There was no significant association between time-averaged serum calcium categories and risk of graft failure censored death, DGF, and AR.
conclusionsIn this cohort, hemodialysis patients with pretransplant serum alkaline phosphatase >120 U/L have unfavorable post-transplant mortality, whereas there was no association between serum PTH and serum calcium levels and post-transplant outcomes.
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