ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity.
Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Kidney Health and Gender-Affirming Hormone Therapy for Transgender and Gender Diverse Individuals.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- Mechanisms and consequences of sex differences in immune responses.Nature reviews. Nephrology · 2024Review
- Oxidative stress and senescence in aging kidneys: the protective role of SIRT1.EXCLI journal · 2024Review
- Sexual dimorphic response to rituximab treatment: A longitudinal observational study in a large cohort of patients with primary membranous nephropathy and persistent nephrotic syndrome.Frontiers in pharmacology · 2022Article
- Gender-biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females.Physiological reports · 2020Article
- Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly.Pharmacology & therapeutics · 2019Review
- Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease.Nature reviews. Nephrology · 2018Review
- Consequences of advanced aging on renal function in chronic hyperandrogenemic female rat model: implications for aging women with polycystic ovary syndrome.Physiological reports · 2017Article
- Aging-associated renal disease in mice is fructokinase dependent.American journal of physiology. Renal physiology · 2016Article
- Sex Differences in Renal Proximal Tubular Cell Homeostasis.Journal of the American Society of Nephrology : JASN · 2016Article
- Sex- and age-related differences in arterial pressure and albuminuria in mice.Biology of sex differences · 2016Article
- Impact of advanced age on the severity of normotensive pulmonary embolism.Heart and vessels · 2015Article
- Blood pressure, sex, and female sex hormones influence renal inner medullary nitric oxide synthase activity and expression in spontaneously hypertensive rats.Journal of the American Heart Association · 2015Article
- Protective role of female gender in programmed accelerated renal aging in the rat.Physiological reports · 2015Article
- Sex-specific alterations in NOS regulation of vascular function in aorta and mesenteric arteries from spontaneously hypertensive rats compared to Wistar Kyoto rats.Physiological reports · 2014Article
- Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor.Biology of sex differences · 2014Article
- Hypertension: what's sex got to do with it?Physiology (Bethesda, Md.) · 2013Review
- Oxidative damage parameters in renal tissues of aged and young rats based on gender.Clinical interventions in aging · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Females develop less age-dependent loss of renal function, which may be in part due to cardiorenal protective effects of estrogens. The impact of androgen level on cardiovascular-renal health is controversial. Estrogen acts through multiple mechanisms, sometimes beneficial, sometimes damaging, which makes it difficult to predict the effect of hormone replacement therapy (HRT) in an aging population. Nitric oxide (NO) deficiency occurs in aging and contributes to age-dependent cardiovascular risk and kidney damage. The increased oxidative stress of aging has effects at multiple sites in the NO biosynthetic pathway to lower NO production/action. Loss of NO together with activated angiotensin promotes some of the decrements in cardiovascular-renal function seen with age, which may be related to actions of the sex steroids.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.