ArticleHealth economics review2012
Methodological considerations in cost of illness studies on Alzheimer disease.
Article in Health economics review, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Adverse Drug Reaction Costs and Study Quality in Africa: A Systematic Review of Cost-of-Illness Studies.PharmacoEconomics - open · 2026Pooled it
- A consensus-based checklist for the critical appraisal of cost-of-illness (COI) studies.International journal of technology assessment in health care · 2023Guideline
- The economic burden of dementia in low- and middle-income countries (LMICs): a systematic review.BMJ global health · 2022Pooled it
- In-hospital costs after severe traumatic brain injury: A systematic review and quality assessment.PloS one · 2019Pooled it
- Cost of diabetes mellitus in Africa: a systematic review of existing literature.Globalization and health · 2018Pooled it
- Systematic review of economic burden of heart failure.Heart failure reviews · 2018Pooled it
- Economic burden of caregiving for persons with severe mental illness in sub-Saharan Africa: A systematic review.PloS one · 2018Pooled it
- Trial
- Global economic burden of diabetic related hypoglycemia: a systematic review of cost of illness studies.Health economics review · 2025Review
- Economic analysis of triclosan-coated versus uncoated sutures at preventing surgical site infection in patients undergoing abdominal surgery.BMJ surgery, interventions, & health technologies · 2025Article
- Primary Causes and Direct Medical Cost of Heart Failure Among Adults Admitted with Acute Decompensated Heart Failure in a Public Tertiary Hospital, Kenya.Global heart · 2025Article
- Cost of illness of breast cancer in low- and middle-income countries: a systematic review.Health economics review · 2024Review
- The economic burden of bipolar disorder: a case study in Southern Iran.Cost effectiveness and resource allocation : C/E · 2024Article
- Economic burden of diabetic foot ulcer: a case of Iran.BMC health services research · 2024Article
- The True Price of External Health Effects from Food Consumption.Nutrients · 2023Article
- Expert opinion on a consensus-based checklist for the critical appraisal of cost-of-illness (COI) studies: qualitative interviews.International journal of technology assessment in health care · 2023Article
- Economic Burden of Multiple Sclerosis Drugs in Iran during 2011-2019.Iranian journal of public health · 2023Article
- The economic burden of obesity in Italy: a cost-of-illness study.The European journal of health economics : HEPAC : health economics in prevention and care · 2022Article
- Article
- Cost-of-illness study for axillary hyperhidrosis in Japan.The Journal of dermatology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cost-of-illness studies (COI) can identify and measure all the costs of a particular disease, including the direct, indirect and intangible dimensions. They are intended to provide estimates about the economic impact of costly disease. Alzheimer disease (AD) is a relevant example to review cost of illness studies because of its costliness.The aim of this study was to review relevant published cost studies of AD to analyze the method used and to identify which dimension had to be improved from a methodological perspective. First, we described the key points of cost study methodology. Secondly, cost studies relating to AD were systematically reviewed, focussing on an analysis of the different methods used. The methodological choices of the studies were analysed using an analytical grid which contains the main methodological items of COI studies. Seventeen articles were retained. Depending on the studies, annual total costs per patient vary from $2,935 to $52, 954. The methods, data sources, and estimated cost categories in each study varied widely. The review showed that cost studies adopted different approaches to estimate costs of AD, reflecting a lack of consensus on the methodology of cost studies. To increase its credibility, closer agreement among researchers on the methodological principles of cost studies would be desirable.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.