Evidence map›Paper›PMID 22974061›Full record

Trial reportJournal of intellectual disability research : JIDR2013

Is body mass index a useful measure of excess body fatness in adolescents and young adults with Down syndrome?

L G Bandini, R K Fleming, R Scampini, J Gleason, A Must

Open access · greenAbstract readClinical TrialValidation Study
In one paragraph

Trial report in Journal of intellectual disability research : JIDR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 46 citations in OpenAlex.

  1. The combination of atomoxetine and oxybutynin for the treatment of obstructive sleep apnea in children with Down syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Trial
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  8. Foot and ankle deformities in children with Down syndrome.Journal of children's orthopaedics · 2018
    Article
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  12. Effects of two programs of exercise on body composition of adolescents with Down syndrome.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2014
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

L G BandiniEunice Kennedy Shriver Center, University of Massachusetts Medical School, Waltham, MA, USA Department of Health Sciences, Boston University, Boston, MA, USA Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
R K Fleming
R Scampini
J Gleason
A Must
University of Massachusetts Chan Medical School · USEunice Kennedy Shriver Center · USTufts University · US

Funding

ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI GRINSPOON, STEVEN K. · 1985 to 2008
$37.4M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0M
TISSUE CULTURE CORE FACILITYP30HD004147 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KENNEDY, DAVID NELSON · 1985 to 2014
$9.1M
NCRR NIH HHS M01 RR001066NCRR NIH HHS MO1-RR001066NICHD NIH HHS P30 HD004147NIDDK NIH HHS P30 DK046200
6 · The paper itself

Abstract

backgroundTo determine the validity of body mass index (BMI) to identify excess fatness in youth with Down syndrome (DS).

methodsUsing the Centers for Disease Control and Prevention (CDC) growth reference, we defined overweight (≥ 85th percentile) and obesity (≥ 95th percentile) based on participants' age- and sex-specific BMI z-scores, calculated from measured height and weight. Percentage body fat was measured by dual-energy X-ray absorptiometry. We determined sensitivity, specificity, positive predictive value, negative predictive value and efficiency of BMI percentiles to identify excess adiposity relative to elevated percentage body fat cut-offs developed from the Pediatric Rosetta Body Composition project in 32 youth (20 boys/12 girls), ages 13-21 years with Down syndrome.

resultsFor adolescents with Down syndrome using the cut-off points of 95th percentile for BMI (obesity), sensitivity and specificity were 71% and 96% respectively. Positive predictive value was 83% and negative predictive value was 92%. Overall efficiency was 91%. Sensitivity and specificity for BMI cut-offs above the 85th percentile (overweight) were 100% and 60% respectively. The positive predictive value was 41% and negative predictive value was 100%. Overall efficiency was 69%.

conclusionOn the whole, the obesity (≥ 95th percentile) cut-off performs better than the overweight cut-off (85th-94th percentile) in identifying elevated fatness in youth with DS.

Indexed as

Body Mass IndexAdolescentAnthropometryBody CompositionDown SyndromeFemaleGrowth ChartsHumansMaleObesity, AbdominalOverweightPredictive Value of TestsReproducibility of ResultsSensitivity and SpecificityYoung Adultadolescentsbody fatnessbody mass indexDown syndromeobesity

Identifiers

PMID22974061
PMCPMC4019440
OpenAlexW2122313620

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.