ArticleRespiratory medicine2012
Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: the MESA Lung Study.
Article in Respiratory medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Association of PiSlope with lung function decline in individuals with preserved spirometry: a prospective cohort study.ERJ open research · 2026Article
- Automated CT-based decoupling of the effects of airway narrowing and wall thinning on airway counts in chronic obstructive pulmonary disease.The British journal of radiology · 2025Article
- Indices of Childhood Socioeconomic Status and Dysanapsis among Older Adults: The Multi-Ethnic Study of Atherosclerosis Lung Study.Annals of the American Thoracic Society · 2024Article
- CT-derived pectoralis composition and incident pneumonia hospitalization using fully automated deep-learning algorithm: multi-ethnic study of atherosclerosis.European radiology · 2024Article
- Airway Tree Caliber and Susceptibility to Pollution-associated Emphysema: MESA Air and Lung Studies.American journal of respiratory and critical care medicine · 2024Article
- Chest CT-based automated vertebral fracture assessment using artificial intelligence and morphologic features.Medical physics · 2024Article
- Quantitative CT Analysis Based on Smoking Habits and Chronic Obstructive Pulmonary Disease in Patients with Normal Chest CT.Journal of the Korean Society of Radiology · 2023Article
- Review
- Association of dysanapsis with mortality among older adults.The European respiratory journal · 2023Article
- Airway Detection in COPD at Low-Dose CT Using Deep Learning and Multiparametric Freeze and Grow.Radiology. Cardiothoracic imaging · 2022Article
- Chronic exposure to diesel exhaust may cause small airway wall thickening without lumen narrowing: a quantitative computerized tomography study in Chinese diesel engine testers.Particle and fibre toxicology · 2021Article
- A CT-Based Automated Algorithm for Airway Segmentation Using Freeze-and-Grow Propagation and Deep Learning.IEEE transactions on medical imaging · 2021Article
- Small Airway Wall Thickening Assessed by Computerized Tomography Is Associated With Low Lung Function in Chinese Carbon Black Packers.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- LOCALLY ADAPTIVE HALF-MAX METHODS FOR AIRWAY LUMEN-AREA AND WALL-THICKNESS AND THEIR REPEAT CT SCAN REPRODUCIBILITY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2020Article
- A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography.American journal of respiratory and critical care medicine · 2019Article
- Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).Respiratory research · 2019Article
- Prediction of Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease: Correlation with Quantitative CT Parameters.Korean journal of radiology · 2019Article
- Prognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study.Annals of the American Thoracic Society · 2018Article
- Chronic Obstructive Pulmonary Disease in Hispanics. A 9-Year Update.American journal of respiratory and critical care medicine · 2018Review
- Differences in Respiratory Symptoms and Lung Structure Between Hispanic and Non-Hispanic White Smokers: A Comparative Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2017Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAutopsy studies show that smoking contributes to airway wall hyperplasia and narrowing of the airway lumen. Studies of smoking and airway measures on computed tomography (CT) scan are limited to case-control studies of measures that combine airway lumen and wall thickness.
objectivesWe hypothesized that cumulative cigarette smoking would be associated with increased airway wall thickness in a large, population-based cohort.
methodsThe Multi-Ethnic Study of Atherosclerosis enrolled participants age 45-84 years from the general population. Smoking history was assessed via standardized questionnaire items; current smoking was confirmed in half the cohort with cotinine. Airway lumen and wall thickness were measured in two dimensions in posterior basal segmental bronchi on cardiac-gated CT scans. Analyses were adjusted for age, gender, genetic ancestry, education, height, weight, asthma history, particulate matter, scanner type, and scanner current.
resultsHalf of the 7898 participants had smoked and 14% were current smokers. Pack-years of smoking were associated with thicker airway walls (mean increase 0.002 mm per ten pack-years [95% CI: 0.00002, 0.004] p = 0.03). Current smoking was associated with narrower airway lumens (mean decrease -0.11 mm [95% CI: -0.2, -0.02] p = 0.02). There was no evidence that either association was modified by genetic ancestry, and findings persisted among participants without clinical disease.
conclusionsLong-term cigarette smoking was associated with subclinical increases in wall thickness of sub-segmental airways whereas current smoking was associated with narrower airway lumen diameters. Smoking may contribute to airway wall thickening prior to the development of overt chronic obstructive pulmonary disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.