ArticleMenopause (New York, N.Y.)2013
Progression rates of carotid intima-media thickness and adventitial diameter during the menopausal transition.
Article in Menopause (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06975111 (Focusing on the Menopausal Transition to Improve Mid-Life Women's Health), which is not on this map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Focusing on the Menopausal Transition to Improve Mid-Life Women's Health
Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.
- Cardiovascular Changes in Menopause.Current cardiology reviews · 2021Pooled it
- A Pilot Study to Describe Cardiometabolic Health Indicators and Prescription Medication Use in Postmenopausal Women with a Self-Reported History of PMOS.Journal of clinical medicine · 2026Article
- Age moderates the association between handgrip strength and large artery stiffness in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Review
- Cardiovascular Health in Women-Across the Lifespan.Clinical endocrinology · 2026Review
- Cardiovascular Health Characterization Using Life's Essential 8 Score in Perimenopausal Women: An Analysis of the National Health and Nutritional Examination Survey.Journal of the American Heart Association · 2026Article
- Review
- Endocrine enigmas: vascular health in females throughout the lifespan.American journal of physiology. Heart and circulatory physiology · 2025Review
- Cardiovascular Risk Associated with Menopause and Menopause Hormone Therapy: A Review and Contemporary Approach to Risk Assessment.Current atherosclerosis reports · 2025Review
- Targeting NLRP3 inflammasome attenuates cardiac pyroptosis and fibrosis in estrogen-deficient diabetic rats.Pflugers Archiv : European journal of physiology · 2025Article
- Cardiovascular Disease Risk in Women with Menopause.Journal of clinical medicine · 2025Review
- Article
- Higher amounts of habitual physical activity changes the relationship between hot flashes and subclinical cardiovascular disease risk.Physiological reports · 2025Article
- Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.GeroScience · 2025Review
- Ischemic Stroke in Women: Understanding Sex-Specific Risk Factors, Treatment Considerations, and Outcomes.Journal of cardiovascular development and disease · 2024Review
- The 100 top-cited articles in menopausal syndrome: a bibliometric analysis.Reproductive health · 2024Article
- Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV.The Journal of infectious diseases · 2024Article
- The menopausal transition period and cardiovascular risk.Nature reviews. Cardiology · 2024Review
- Trajectories of Sleep Over Midlife and Incident Cardiovascular Disease Events in the Study of Women's Health Across the Nation.Circulation · 2024Article
- Psychological stress and the longitudinal progression of subclinical atherosclerosis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study is to assess whether the levels and progression rates of carotid intima-media thickness (IMT) and adventitial diameter (AD) vary by menopausal stage.
methodsTwo hundred forty-nine women (aged 42-57 y; 49% premenopausal and 46% early perimenopausal) from the Study of Women's Health Across the Nation were included in the current analysis. Participants were followed up for up to 9 years (median, 3.7 y) and underwent up to five carotid scans. Linear mixed-effect models were used for the analysis.
resultsThe overall rate of change in IMT was 0.007 mm/year. Independent of age and race, the progression rate of IMT increased substantially in the late perimenopausal stage (0.017 mm/y) compared with both the premenopausal stage (0.007 mm/y) and the early perimenopausal stage (0.005 mm/y; P ≤ 0.05). For AD, although the overall rate of change was negative (-0.009 mm/y), significant positive increases in the rate of change were observed in the late perimenopausal stage (0.024 mm/y) and the postmenopausal stage (0.018 mm/y) compared with the premenopausal stage (-0.032 mm/y; P < 0.05). In the final models, the postmenopausal stage was independently associated with higher levels of IMT and AD (P < 0.05) compared with the premenopausal stage.
conclusionsDuring the menopausal transition, the carotid artery undergoes adaptation that is reflected in adverse changes in IMT and AD. These changes may have an impact on the vulnerability of the vessel to disease in older women.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.