ArticleBiophysical journal2012
Interfacial tension and surface pressure of high density lipoprotein, low density lipoprotein, and related lipid droplets.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Cholesteryl Esters Modulate Lipid Droplet Rigidity and Monolayer Organization during Liver Cancer Progression.bioRxiv : the preprint server for biology · 2026Article
- Cytoplasmic abundant heat-soluble proteins from tardigrades protect synthetic cells under stress.Nature communications · 2026Article
- Locally ordered junctions govern diffusion in triglycerides: insights from molecular dynamics simulations.RSC advances · 2025Article
- Article
- Factors Promoting Lipopolysaccharide Uptake by Synthetic Lipid Droplets.bioRxiv : the preprint server for biology · 2024Article
- Ruptures of mixed lipid monolayers under tension and supercooling: implications for nanobubbles in plants.Nanoscale advances · 2024Article
- Macromolecular Interactions of Lipoprotein Lipase (LPL).Sub-cellular biochemistry · 2024Review
- Effects of Lysophospholipid on Growth Performance, Hepatopancreas Health, and Intestinal Microbiome ofAquaculture nutrition · 2024Article
- The dilatable membrane of oleosomes (lipid droplets) allows theirSoft matter · 2023Article
- Study of trioleoylglycerol two-layer and adiposome cross-section mimicking four-layer systems through atomic-level simulations.Structural dynamics (Melville, N.Y.) · 2022Article
- Effects of Compound Feed Attractants on Growth Performance, Feed Utilization, Intestinal Histology, Protein Synthesis, and Immune Response of White Shrimp (Animals : an open access journal from MDPI · 2022Article
- Computational Studies of Lipid Droplets.The journal of physical chemistry. B · 2022Review
- Recharging your fats: CHARMM36 parameters for neutral lipids triacylglycerol and diacylglycerol.Biophysical reports · 2021Article
- Structure and intermolecular interactions in spheroidal high-density lipoprotein subpopulations.Journal of structural biology: X · 2021Article
- The Surface and Hydration Properties of Lipid Droplets.Biophysical journal · 2020Article
- Self-Assembly of Polymer-Encased Lipid Nanodiscs and Membrane Protein Reconstitution.The journal of physical chemistry. B · 2019Article
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Molecular dynamics simulations of lipid nanodiscs.Biochimica et biophysica acta. Biomembranes · 2018Article
- Molecular Mechanism of Lipid Nanodisk Formation by Styrene-Maleic Acid Copolymers.Biophysical journal · 2018Article
- A correlation between secondary structure and rheological properties of low-density lipoproteins at air/water interfaces.Journal of biological physics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid droplets play a central role in energy storage and metabolism on a cellular scale. Their core is comprised of hydrophobic lipids covered by a surface region consisting of amphiphilic lipids and proteins. For example, high and low density lipoproteins (HDL and LDL, respectively) are essentially lipid droplets surrounded by specific proteins, their main function being to transport cholesterol. Interfacial tension and surface pressure of these particles are of great interest because they are related to the shape and the stability of the droplets and to protein adsorption at the interface. Here we use coarse-grained molecular-dynamics simulations to consider a number of related issues by calculating the interfacial tension in protein-free lipid droplets, and in HDL and LDL particles mimicking physiological conditions. First, our results suggest that the curvature dependence of interfacial tension becomes significant for particles with a radius of ∼5 nm, when the area per molecule in the surface region is <1.4 nm(2). Further, interfacial tensions in the used HDL and LDL models are essentially unaffected by single apo-proteins at the surface. Finally, interfacial tensions of lipoproteins are higher than in thermodynamically stable droplets, suggesting that HDL and LDL are kinetically trapped into a metastable state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.