Evidence map›Paper›PMID 23009606›Full record

ArticleNutrition & metabolism2012

Periodontal disease: the influence of metabolic syndrome.

Enrico Marchetti, Annalisa Monaco, Laura Procaccini, Stefano Mummolo, Roberto Gatto, Stefano Tetè, Alberto Baldini, Simona Tecco, Giuseppe Marzo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Enrico Marchetti *Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Annalisa MonacoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Laura ProcacciniDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Stefano MummoloDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Roberto GattoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Stefano TetèDepartment of Oral Science, Nano and Biotechnology, University of Chieti, Chieti, Italy.
Alberto BaldiniDepartment of Oral Science, University of Tor Vergata, Rome, Italy.
Simona Tecco *Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Giuseppe MarzoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
University of L'Aquila · ITUniversity of Chieti-Pescara · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include obesity, impaired glucose tolerance or diabetes, hyperinsulinemia, hypertension, and dyslipidemia. Recently, more attention has been reserved to the correlation between periodontitis and systemic health. MetS is characterized by oxidative stress, a condition in which the equilibrium between the production and the inactivation of reactive oxygen species (ROS) becomes disrupted. ROS have an essential role in a variety of physiological systems, but under a condition of oxidative stress, they contribute to cellular dysfunction and damage. Oxidative stress may act as a common link to explain the relationship between each component of MetS and periodontitis. All those conditions show increased serum levels of products derived from oxidative damage, promoting a proinflammatory state. Moreover, adipocytokines, produced by the fat cells of fat tissue, might modulate the balance between oxidant and antioxidant activities. An increased caloric intake involves a higher metabolic activity, which results in an increased production of ROS, inducing insulin resistance. At the same time, obese patients require more insulin to maintain blood glucose homeostasis - a state known as hyperinsulinemia, a condition that can evolve into type 2 diabetes. Oxidation products can increase neutrophil adhesion and chemotaxis, thus favoring oxidative damage. Hyperglycemia and an oxidizing state promote the genesis of advanced glycation end-products, which could also be implicated in the degeneration and damage of periodontal tissue. Thus, MetS, the whole of interconnected factors, presents systemic and local manifestations, such as cardiovascular disease and periodontitis, related by a common factor known as oxidative stress.

Identifiers

PMID23009606
PMCPMC3499456
OpenAlexW2146040383

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.