ArticleMolecules (Basel, Switzerland)2012
Inhibitory effects of resveratrol analogs on mushroom tyrosinase activity.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Skin-Lightening Efficacy of Leatherleaf Fern Extract and a Leatherleaf Fern-Based Facial Serum In Vitro and Clinical Trial.Journal of cosmetic dermatology · 2026Article
- Screening and Evaluation of Dermo-Cosmetic Activities of the Invasive Plant SpeciesPlants (Basel, Switzerland) · 2022Article
- Dual Antimelanogenic Effect of Nicotinamide-Stabilized Phloretin Nanocrystals in Larval Zebrafish.Pharmaceutics · 2022Article
- Selecting and Characterizing Tyrosinase Inhibitors fromJournal of analytical methods in chemistry · 2021Article
- A comprehensive review on tyrosinase inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2019Review
- Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications.Antioxidants (Basel, Switzerland) · 2019Review
- Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2017Review
- The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol.Molecules (Basel, Switzerland) · 2016Article
- Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin.Biomolecules & therapeutics · 2016Article
- Synthesis and Biological Evaluation of Resveratrol Derivatives as Melanogenesis Inhibitors.Molecules (Basel, Switzerland) · 2015Article
- Resveratrol-Enriched Rice Down-Regulates Melanin Synthesis in UVB-Induced Guinea Pigs Epidermal Skin Tissue.Biomolecules & therapeutics · 2014Article
- Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin.Biomolecules & therapeutics · 2014Article
- Azastilbene analogs as tyrosinase inhibitors: new molecules with depigmenting potential.TheScientificWorldJournal · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin pigmentation disorders typically involve an overproduction or uneven distribution of melanin, which results in skin spots. Resveratrol can inhibit tyrosinase, the active enzyme in the synthesis of melanin, but it does not inhibit the synthesis of melanin to an extent that enables its use alone as a skin whitening agent in pharmaceutical formulations, so its use as a coadjuvant in treatment of hyperpigmentation is suggested. Six resveratrol analogs were tested for tyrosinase inhibitory activity in vitro. Among the analogs tested, compound D was the most powerful tyrosinase inhibitor (IC(50) = 28.66 µg/mL), two times more active than resveratrol (IC(50) = 57.05 µg/mL), followed by the analogs A, E, B, F and C, respectively. This demonstrated that the hydroxylation at C4' on the phenolic ring was the molecular modification with most importance for the observed activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.