ArticleGenetics2012
Functional characterization of Drosophila microRNAs by a novel in vivo library.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- microRNAs affecting development of body pigmentation in adult Drosophila melanogaster.bioRxiv : the preprint server for biology · 2026Article
- mir-276a Is Required for Muscle Development inCells · 2025Article
- Characterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman-mediated regulation of the highly conserved let-7 cluster during apoptotic processes.Frontiers in genetics · 2024Article
- Characterisation of the role and regulation ofFrontiers in cell and developmental biology · 2023Article
- miR-277 regulates the phase of circadian activity-rest rhythm inFrontiers in physiology · 2023Article
- The MicroRNAMetabolites · 2022Article
- Resources and Methods for the Analysis of MicroRNA Function in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2022Review
- A comprehensive in vivo screen for anti-apoptotic miRNAs indicates broad capacities for oncogenic synergy.Developmental biology · 2021Article
- Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression.Genes · 2019Review
- MicroRNAs in Drosophila Cancer Models.Advances in experimental medicine and biology · 2019Review
- miRNAs in Insects Infected by Animal and Plant Viruses.Viruses · 2018Review
- Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution.PLoS genetics · 2018Article
- Stress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes ribonucleoprotein granule formation and cell survival.Nature communications · 2018Article
- The in vivo genetic toolkit for studying expression and functions of Drosophila melanogaster microRNAs.RNA biology · 2017Review
- An accelerated miRNA-based screen implicates Atf-3 in Drosophila odorant receptor expression.Scientific reports · 2016Article
- A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development.Genome research · 2015Article
- The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs.RNA biology · 2015Article
- Hunting the needle in the haystack: a guide to obtain biologically meaningful microRNA targets.International journal of molecular sciences · 2014Review
- Review
- Pleiotropic constraints, expression level, and the evolution of miRNA sequences.Journal of molecular evolution · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Animal microRNAs (miRNA) are implicated in the control of nearly all cellular functions. Due to high sequence redundancy within the miRNA gene pool, loss of most of these 21- to 24-bp long RNAs individually does not cause a phenotype. Thus, only very few miRNAs have been associated with clear functional roles. We constructed a transgenic UAS-miRNA library in Drosophila melanogaster that contains 180 fly miRNAs. This library circumvents the redundancy issues by facilitating the controlled misexpression of individual miRNAs and is a useful tool to complement loss-of-function approaches. Demonstrating the effectiveness of our library, 78 miRNAs induced clear phenotypes. Most of these miRNAs were previously unstudied. Furthermore, we present a simple system to create GFP sensors to monitor miRNA expression and test direct functional interactions in vivo. Finally, we focus on the miR-92 family and identify a direct target gene that is responsible for the specific wing phenotype induced by the misexpression of miR-92 family members.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.