Evidence map›Paper›PMID 23056394›Full record

ArticlePloS one2012

Inappropriate drugs in elderly patients with severe cognitive impairment: results from the shelter study.

Giuseppe Colloca, Matteo Tosato, Davide L Vetrano, Eva Topinkova, Daniela Fialova, Jacob Gindin, Henriëtte G van der Roest, Francesco Landi, Rosa Liperoti, Roberto Bernabei and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
10.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  12. Polypharmacy patterns in the last year of life in patients with dementia.European journal of clinical pharmacology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Giuseppe CollocaCentro Medicina dell'Invecchiamento, Università Cattolica Sacro Cuore, Rome, Italy. giuseppe.colloca@rm.unicatt.it
Matteo Tosato
Davide L Vetrano
Eva Topinkova
Daniela Fialova
Jacob Gindin
Henriëtte G van der Roest
Francesco Landi
Rosa Liperoti
Roberto Bernabei
Graziano Onder
SHELTER project
Università Cattolica del Sacro Cuore · ITCharles University · CZEMGO Institute for Health and Care Research · NLUniversity of Haifa · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been estimated that Nursing Home (NH) residents with impaired cognitive status receive an average of seven to eight drugs daily. The aim of this study was to determine prevalence and factors associated with use of inappropriate drugs in elderly patients with severe cognitive impairment living in NH in Europe.

methodsCross-sectional data from a sample of 1449 NH residents with severe cognitive impairment, participating in the Services and Health for Elderly in Long TERm care (SHELTER) study were analysed. Inappropriate drug use was defined as the use of drugs classified as rarely or never appropriate in patients with severe cognitive impairment based on the Holmes criteria published in 2008.

resultsMean age of participating residents was 84.2±8.9 years, 1087 (75.0%) were women. Inappropriate drug use was observed in 643 (44.9%) residents. Most commonly used inappropriate drugs were lipid-lowering agents (9.9%), antiplatelet agents (excluding Acetylsalicylic Acid - ASA -) (9.9%), acetylcholinesterase, inhibitors (7.2%) and antispasmodics (6.9%). Inappropriate drug use was directly associated with specific diseases including diabetes (OR 1.64; 95% CI 1.21-2.24), heart failure (OR 1.48; 95% CI 1.04-2.09), stroke (OR 1.43; 95% CI 1.06-1.93), and recent hospitalization (OR 1.69; 95% CI 1.20-2.39). An inverse relation was shown between inappropriate drug use and presence of a geriatrician in the facility (OR 0.55; 95% CI 0.39-0.77).

conclusionUse of inappropriate drugs is common among older EU NH residents. Determinants of inappropriate drug use include comorbidities and recent hospitalization. Presence of a geriatrician in the facility staff is associated with a reduced rate of use of these medications.

Indexed as

AgedAged, 80 and overAspirinCholinesterase InhibitorsCognition DisordersCross-Sectional StudiesFemaleHealth Services for the AgedHomes for the AgedHumansHypolipidemic AgentsLong-Term CareMaleParasympatholyticsAspirinCholinesterase InhibitorsHypolipidemic AgentsParasympatholytics

Identifiers

PMID23056394
PMCPMC3463565
OpenAlexW2147707282

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.