ArticleImmunogenetics2013
Characterisation of four major histocompatibility complex class II genes of the koala (Phascolarctos cinereus).
Article in Immunogenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Koala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches.Scientific reports · 2024Article
- Using bioinformatics to investigate functional diversity: a case study of MHC diversity in koalas.Immunogenetics · 2024Article
- Epidemiology, Transmission Mode, and Pathogenesis ofAnimals : an open access journal from MDPI · 2024Review
- Plethora of New Marsupial Genomes Informs Our Knowledge of Marsupial MHC Class II.Genome biology and evolution · 2024Article
- Immunohistochemical characterization of the immune cell response during chlamydial infection in the male and female koala (Veterinary pathology · 2024Article
- Best genome sequencing strategies for annotation of complex immune gene families in wildlife.GigaScience · 2022Article
- A targeted approach to investigating immune genes of an iconic Australian marsupial.Molecular ecology · 2022Article
- The Koala Immune Response to Chlamydial Infection and Vaccine Development-Advancing Our Immunological Understanding.Animals : an open access journal from MDPI · 2021Review
- High-throughput immunogenetic typing of koalas suggests possible link between MHC alleles and cancers.Immunogenetics · 2020Article
- Therapeutic vaccination of koalas harbouring endogenous koala retrovirus (KoRV) improves antibody responses and reduces circulating viral load.NPJ vaccines · 2020Article
- The relative contribution of causal factors in the transition from infection to clinical chlamydial disease.Scientific reports · 2018Article
- Characterisation of MHC class I genes in the koala.Immunogenetics · 2018Article
- Article
- Identification, characterisation and expression analysis of natural killer receptor genes in Chlamydia pecorum infected koalas (Phascolarctos cinereus).BMC genomics · 2015Article
- Immunomics of the koala (Phascolarctos cinereus).Immunogenetics · 2015Article
- SNP marker discovery in koala TLR genes.PloS one · 2015Article
- MHC class II diversity of koala (Phascolarctos cinereus) populations across their range.Heredity · 2014Article
- Identification of MHCII variants associated with chlamydial disease in the koala (Phascolarctos cinereus).PeerJ · 2014Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) class II molecules have an integral role in the adaptive immune response, as they bind and present antigenic peptides to T helper lymphocytes. In this study of koalas, species-specific primers were designed to amplify exon 2 of the MHC class II DA and DB genes, which contain much of the peptide-binding regions of the α and β chains. A total of two DA α1 domain variants and eight DA β1 (DAB), three DB α1 and five DB β1 variants were amplified from 20 koalas from two free-living populations from South East Queensland and the Port Macquarie region in northern New South Wales. We detected greater variation in the β1 than in the α1 domains as well as evidence of positive selection in DAB. The present study provides a springboard to future investigation of the role of MHC in disease susceptibility in koalas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.