Evidence map›Paper›PMID 23100244›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2013

Behavioral paradigms to evaluate PPAR modulation in animal models of brain injury.

Dana Greene-Schloesser, Caroline I Schnegg, Mike E Robbins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dana Greene-SchloesserDepartments of Radiation Oncology and Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Caroline I Schnegg
Mike E Robbins

Funding

Training Program in Cancer BiologyT32CA079448 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2000 to 2005
$2.3M
PPARs and Radiation-induced Brain InjuryR01CA112593 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2004 to 2005
$588k
Training Program in Translational Radiation OncologyT32CA113267 · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2005 to 2005
$133k
NCI NIH HHS CA112593NCI NIH HHS CA113267NCI NIH HHS R01 CA112593NCI NIH HHS T32 CA079448NCI NIH HHS T32 CA113267
6 · The paper itself

Abstract

The use of behavioral testing has become an invaluable tool for assessing the efficacy of therapeutics for a variety of disorders of the central nervous system. This chapter will describe in detail several behavioral paradigms to evaluate the efficacy of PPAR agonists to modulate cognitive impairments in rodent models. When used together as a battery these procedures allow for a global assessment of cognition. These tests are explained in detail below, and include: (1) Novel Object Recognition (NOR), (2) Morris Water Maze (MWM), (3) Delay Match to Place (DMP), and (4) Cue Strategy.

Indexed as

Neuropsychological TestsAnimalsBehavior, AnimalBrain InjuriesCuesDisease Models, AnimalMaze LearningPeroxisome Proliferator-Activated ReceptorsTreatment OutcomePeroxisome Proliferator-Activated Receptors

Identifiers

PMID23100244
PMCPMC3795415

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.