ArticleNanomedicine (London, England)2013
Functional interaction between charged nanoparticles and cardiac tissue: a new paradigm for cardiac arrhythmia?
Article in Nanomedicine (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Integrated Analysis of Behavioral and Physiological Effects of Nano-Sized Carboxylated Polystyrene Particles onBiosensors · 2025Article
- Review
- Opto-SICM framework combines optogenetics with scanning ion conductance microscopy for probing cell-to-cell contacts.Communications biology · 2023Article
- Invited Perspective: The Silent Threat-Air Pollution's Link to Arrhythmias.Environmental health perspectives · 2023Article
- Three-Dimensional Bioprinting of Organoid-Based Scaffolds (OBST) for Long-Term Nanoparticle Toxicology Investigation.International journal of molecular sciences · 2023Article
- Antifungal Effect of Nanoparticles against COVID-19 Linked Black Fungus: A Perspective on Biomedical Applications.International journal of molecular sciences · 2022Review
- Scanning Ion Conductance Microscopy.Chemical reviews · 2021Review
- Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes.Particle and fibre toxicology · 2021Article
- Fabrication of Double Emission Enhancement Fluorescent Nanoparticles with Combined PET and AIEE Effects.Molecules (Basel, Switzerland) · 2020Article
- Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats.Particle and fibre toxicology · 2019Article
- Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats.Journal of nanobiotechnology · 2019Article
- Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function.Oxidative medicine and cellular longevity · 2019Article
- Silica nanoparticles induce cardiotoxicity interfering with energetic status and CaAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- Article
- Differential bioreactivity of neutral, cationic and anionic polystyrene nanoparticles with cells from the human alveolar compartment: robust response of alveolar type 1 epithelial cells.Particle and fibre toxicology · 2015Article
- Nanoparticles modulate surfactant protein A and D mediated protection against influenza A infection in vitro.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue.Particle and fibre toxicology · 2014Article
- Up-regulation of mRNA ventricular PRNP prion protein gene expression in air pollution highly exposed young urbanites: endoplasmic reticulum stress, glucose regulated protein 78, and nanosized particles.International journal of molecular sciences · 2013Article
- CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.Cell death & disease · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
aimTo investigate the effect of surface charge of therapeutic nanoparticles on sarcolemmal ionic homeostasis and the initiation of arrhythmias. MATERIALS &
methodsCultured neonatal rat myocytes were exposed to 50 nm-charged polystyrene latex nanoparticles and examined using a combination of hopping probe scanning ion conductance microscopy, optical recording of action potential characteristics and patch clamp.
resultsPositively charged, amine-modified polystyrene latex nanoparticles showed cytotoxic effects and induced large-scale damage to cardiomyocyte membranes leading to calcium alternans and cell death. By contrast, negatively charged, carboxyl-modified polystyrene latex nanoparticles (NegNPs) were not overtly cytotoxic but triggered formation of 50-250-nm nanopores in the membrane. Cells exposed to NegNPs revealed pro-arrhythmic events, such as delayed afterdepolarizations, reduction in conduction velocity and pathological increment of action potential duration together with an increase in ionic current throughout the membrane, carried by the nanopores.
conclusionThe utilization of charged nanoparticles is a novel concept for targeting cardiac excitability. However, this unique nanoscopic investigation reveals an altered electrophysiological substrate, which sensitized the heart cells towards arrhythmias.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.