Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2013
Effect of more frequent hemodialysis on cognitive function in the frequent hemodialysis network trials.
Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023Pooled it
- Home versus in-centre haemodialysis for end-stage kidney disease.The Cochrane database of systematic reviews · 2014Pooled it
- Long-Term Effects of Frequent In-Center Hemodialysis.Journal of the American Society of Nephrology : JASN · 2016Trial
- Microbiota-derived metabolites and cognitive dysfunction in dialysis patients: mechanisms and targeted therapeutic strategies.Frontiers in microbiology · 2026Review
- Dialysis and cognitive impairment.Nature reviews. Nephrology · 2025Review
- Diagnosis and Management of Dementia for the Nephrology Clinician: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Interventions to improve cognitive performance in chronic kidney disease: A scoping review.PloS one · 2025Article
- Cognitive impairment in patients on dialysis: can we prevent it?Journal of nephrology · 2024Review
- Elevated HIF-1α levels in maintenance hemodialysis patients: a potential link to increased cognitive impairment risk.Frontiers in aging neuroscience · 2024Article
- A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodialysis in Southern Spain.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Epidemiology of haemodialysis outcomes.Nature reviews. Nephrology · 2022Review
- Correlation between home systolic blood pressure variability and cognitive impairment in maintenance hemodialysis patients.Seminars in dialysis · 2022Article
- Insights into Cognitive Brain Health in Chronic Kidney Disease.Gerontology & geriatrics : research · 2022Article
- Cognitive Function and Vitamin D Status in the Chinese Hemodialysis Patients.Computational and mathematical methods in medicine · 2022Article
- Association of brachial-ankle pulse wave velocity with cognitive impairment in peritoneal dialysis patients.Renal failure · 2021Article
- Multitargeted interventions to reduce dialysis-induced systemic stress.Clinical kidney journal · 2021Review
- "Is It Removed During Dialysis?"-Cognitive Dysfunction in Advanced Kidney Failure-A Review Article.Frontiers in neurology · 2021Review
- Interventions to Preserve Cognitive Functioning Among Older Kidney Transplant Recipients.Current transplantation reports · 2020Article
- Associations between small and middle molecules clearance and the change of cognitive function in peritoneal dialysis.Journal of nephrology · 2020Article
- Preference for Alternate-Day Versus Conventional In-Center Dialysis: A Health Utility Elicitation.Canadian journal of kidney health and disease · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundCognitive impairment is common in patients with end-stage renal disease receiving hemodialysis 3 times per week. STUDY
designRandomized clinical trial. SETTING &
participants218 individuals participating in the Frequent Hemodialysis Network (FHN) Daily Trial and 81 participating in the FHN Nocturnal Trial.
interventionThe Daily Trial tested in-center hemodialysis 6 times per week versus 3 times per week. The Nocturnal Trial tested home nocturnal hemodialysis 6 times per week versus home or in-center hemodialysis 3 times per week. OUTCOMES: Cognitive function was measured at baseline, month 4, and month 12. The primary outcome was performance on the Trail-Making Test, Form B, a measure of executive function, and a secondary outcome was performance on the Modified Mini-Mental State Examination, a measure of global cognition. The domains of attention, psychomotor speed, memory, and verbal fluency were assessed in 59 participants in the Daily Trial and 19 participants in the Nocturnal Trial.
resultsWe found no benefit of frequent hemodialysis in either trial for the primary cognitive outcome (Daily Trial: OR for improvement, 0.99; 95% CI, 0.59-1.66; Nocturnal Trial: OR, 1.19; 95% CI, 0.48-2.96). Similarly, there was no benefit of frequent hemodialysis in either trial on global cognition, the secondary cognitive outcome. Exploratory analyses in the Daily Trial suggested possible benefits of frequent hemodialysis for memory and verbal fluency, but not for attention and psychomotor speed. Exploratory analyses in the Nocturnal Trial suggested no benefit of frequent hemodialysis on attention, psychomotor speed, memory, or verbal fluency. LIMITATIONS: Unblinded intervention, small sample.
conclusionsFrequent hemodialysis did not improve executive function or global cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.