ArticleOptometry and vision science : official publication of the American Academy of Optometry2012
Blood pressure, vessel caliber, and retinal thickness in diabetes.
Article in Optometry and vision science : official publication of the American Academy of Optometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Repeatability and Comparability of Retinal Blood Vessel Caliber Measurements by OCTA.Vision (Basel, Switzerland) · 2023Article
- Factors Associated with Fluctuations in Central Subfield Thickness in Patients with Diabetic Macular Edema Using Diabetic Retinopathy Clinical Research Protocols T and V.Ophthalmology science · 2023Article
- Gender-Specific Risk Factors for the Development of Retinal Changes in Children with Type 1 Diabetes.Journal of personalized medicine · 2021Article
- Imaging the eye and its relevance to diabetes care.Journal of diabetes investigation · 2021Review
- Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy.Journal of diabetes research · 2018Article
- Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside.Journal of diabetes research · 2017Review
- Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes.Diabetes & vascular disease research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
purposeIn this study, we examine the association of blood pressure (BP), retinal thickness (RT), and vessel caliber in patients with type 2 diabetes and high HbA1c (elevated long-term blood glucose) with or without mild or moderate nonproliferative diabetic retinopathy (NPDR).
methodsForty-three patients with type 2 diabetes and high HbA1c measures (23 without NPDR and 20 with mild to moderate NPDR) and 22 age-matched nondiabetic controls participated. The BP, RT (Stratus OCT3), fundus photography, and HbA1c were measured. Correlations between BP, HbA1c, vessel caliber, and RT were evaluated.
resultsDiastolic BP (DBP) is positively and significantly associated with RT in patients with NPDR (p < 0.02). Blood pressure was not associated with RT in patients without NPDR (p = 0.83). There is an association between higher HbA1c and higher DBP within the NPDR group (p < 0.02). Furthermore, HbA1c modifies the slope of the relationship between DBP and RT in NPDR patients. Greater venule diameters and loss of the correlation between decreased arteriole size and increased systolic blood pressure, seen in controls, were observed in patients with and without NPDR.
conclusionsThe results of this study show that HbA1c and BP together have an impact on RT measures of patients with DR. These measures should be considered when evaluating RT in patients with DR both clinically and in future optical coherence tomography studies on this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.