ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Brown adipose tissue and its modulation by a mitochondria-targeted peptide in rat burn injury-induced hypermetabolism.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Continuous and repeat metabolic measurements compared between post-cardiothoracic surgery and critical care patients.BMC pulmonary medicine · 2023Observational
- Article
- A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption.Scientific reports · 2021Article
- Brown adipose tissue recruitment in a rodent model of severe burns.Burns : journal of the International Society for Burn Injuries · 2020Article
- Adipose Tissue Metabolic Function and Dysfunction: Impact of Burn Injury.Frontiers in cell and developmental biology · 2020Review
- Dissociated Oxygen Consumption and Carbon Dioxide Production in the Post-Cardiac Arrest Rat: A Novel Metabolic Phenotype.Journal of the American Heart Association · 2018Article
- Characterization of Brown Adipose-Like Tissue in Trauma-Induced Heterotopic Ossification in Humans.The American journal of pathology · 2017Article
- The metabolic stress response to burn trauma: current understanding and therapies.Lancet (London, England) · 2016Review
- Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics.Burns : journal of the International Society for Burn Injuries · 2016Article
- Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans.Cell reports · 2015Article
- Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue.Shock (Augusta, Ga.) · 2015Article
- Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress.Cell metabolism · 2015Article
- Article
- Alcohol's Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury.Alcohol research : current reviews · 2015Review
- First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics.British journal of pharmacology · 2014Review
- Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model.Burns & trauma · 2013Article
- Does adipose tissue thermogenesis play a role in metabolic health?Journal of obesity · 2013Review
- Cold-stimulated browning graft fat enhances burn wound recovery through accelerating DAMP-ADSC activation.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Hypermetabolism is a prominent feature of burn injury, and altered mitochondria function is presumed to contribute to this state. Recently, brown adipose tissue (BAT) was found to be present not only in rodents but also in humans, and its activity is associated with resting metabolic rate. In this report, we elucidate the relationship between burn injury-induced hypermetabolism and BAT activity and the possible role of the mitochondria-targeted peptide SS31 in attenuating burn injury-induced hypermetabolism by using a rat burn injury model. We demonstrate that burn injury induces morphological changes in interscapular BAT (iBAT). Burn injury was associated with iBAT activation, and this effect was positively correlated with increased energy expenditure. BAT activation was associated with augmentation of mitochondria biogenesis, and UCP1 expression in the isolated iBAT mitochondria. In addition, the mitochondria-targeted peptide SS31 attenuated burn injury-induced hypermetabolism, which was accompanied by suppression of UCP1 expression in isolated mitochondria. Our results suggest that BAT plays an important role in burn injury-induced hypermetabolism through its morphological changes and expression of UCP1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.