ReviewCancer research2012
Engineering approaches for investigating tumor angiogenesis: exploiting the role of the extracellular matrix.
Review in Cancer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- CLK3 regulates tumor angiogenesis by modulating HIF1α ubiquitination.Cancer gene therapy · 2026Article
- Vessel-Derived Decellularized Extracellular Matrices (VdECM): Novel Bio-Engineered Materials for the Wound Healing.Tissue engineering and regenerative medicine · 2023Article
- Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy.Frontiers in cellular neuroscience · 2021Article
- The Potential of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer Based on Body Magnetic Field and Organ-on-the-Chip.Advanced pharmaceutical bulletin · 2019Review
- Bioinspired Hydrogels to Engineer Cancer Microenvironments.Annual review of biomedical engineering · 2017Review
- Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment.Journal of the Royal Society, Interface · 2017Review
- Flow-perfusion bioreactor system for engineered breast cancer surrogates to be used in preclinical testing.Journal of tissue engineering and regenerative medicine · 2017Article
- Implantable tissue isolation chambers for analyzing tumor dynamics in vivo.Lab on a chip · 2016Article
- Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation.Assay and drug development technologies · 2015Article
- Tissue-engineered models of human tumors for cancer research.Expert opinion on drug discovery · 2015Review
- Hydrogels to model 3D in vitro microenvironment of tumor vascularization.Advanced drug delivery reviews · 2014Review
- Biomimetic tissue-engineered systems for advancing cancer research: NCI Strategic Workshop report.Cancer research · 2014Article
- Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting.Biomaterials science · 2014Article
- Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy.ACS nano · 2014Article
- Modeling tumor microenvironments in vitro.Journal of biomechanical engineering · 2014Review
- A novel in vitro model for microvasculature reveals regulation of circumferential ECM organization by curvature.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A major paradigm shift in cancer research is the emergence of multidisciplinary approaches to investigate complex cell behaviors, to elucidate regulatory mechanisms and to identify therapeutic targets. Recently, efforts are focused on the engineering of complex in vitro models, which more accurately recapitulate the growth and progression of cancer. These strategies have proven vital for investigating and targeting the events that control tumor angiogenesis. In this review, we explore how the emerging engineering approaches are being used to unlock the complex mechanisms regulating tumor angiogenesis. Emphasis is placed on models using natural and synthetic biomaterials to generate scaffolds mimicking the extracellular matrix, which is known to play a critical role in angiogenesis. While the models presented in this review are revolutionary, improvements are still necessary and concepts for advancing and perfecting engineering approaches for modeling tumor angiogenesis are proposed. Overall, the marriage between disparate scientific fields is expected to yield significant improvements in our understanding and treatment of cancer.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.