ReviewJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Cardiac autonomic imaging with SPECT tracers.
Review in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Article
- Impaired Cardiac Sympathetic Innervation Increases the Risk of Cardiac Events in Heart Failure Patients with Left Ventricular Hypertrophy and Mechanical Dyssynchrony.Journal of clinical medicine · 2021Article
- Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson's disease.PloS one · 2020Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Role of cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Observational
- Spatial Inhomogeneity of Cardiac Norepinephrine Transport Protein and Meta-[Molecular imaging and biology · 2019Article
- Radiopharmaceuticals for cardiac imaging: Current status and future trends.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- A Comparative Assessment of Cardiovascular Autonomic Reflex Testing and CardiacInternational journal of endocrinology · 2018Article
- Neuro-cardiac imaging has a proven value in patient management: Con.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Anthracycline-induced cardiomyopathy: The search continues.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Cardiac sympathetic activity in chronic heart failure: cardiacNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Review
- ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- It's not all in the numbers.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Effects of catheter-based renal denervation on cardiac sympathetic activity and innervation in patients with resistant hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Principles and techniques of imaging in identifying the substrate of ventricular arrhythmia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Initial Experience with Renal Denervation for the Treatment of Resistant Hypertension - The Utility of Novel Anesthetics and Metaiodobenzylguanidine Scintigraphy (MIBG).The open cardiovascular medicine journal · 2016Article
- Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation.Quantitative imaging in medicine and surgery · 2015Article
- Current status of nuclear cardiology in Japan: Ongoing efforts to improve clinical standards and to establish evidence.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- I-123 MIBG Cardiac Imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radionuclide cardiac imaging has potential to assess underlying molecular, electrophysiologic, and pathophysiologic processes of cardiac disease. An area of current interest is cardiac autonomic innervation imaging with a radiotracer such as (123)I-meta-iodobenzylguanidine ((123)I-mIBG), a norepinephrine analogue. Cardiac (123)I-mIBG uptake can be assessed by planar and SPECT techniques, involving determination of global uptake by a heart-to-mediastinal ratio, tracer washout between early and delayed images, and focal defects on tomographic images. Cardiac (123)I-mIBG findings have consistently been shown to correlate strongly with heart failure severity, pre-disposition to cardiac arrhythmias, and poor prognosis independent of conventional clinical, laboratory, and image parameters. (123)I-mIBG imaging promises to help monitor a patient's clinical course and response to therapy, showing potential to help select patients for an ICD and other advanced therapies better than current methods. Autonomic imaging also appears to help diagnose ischemic heart disease and identify higher risk, as well as risk-stratify patients with diabetes. Although more investigations in larger populations are needed to strengthen prior findings and influence modifications of clinical guidelines, cardiac (123)I-mIBG imaging shows promise as an emerging technique for recognizing and following potentially life-threatening conditions, as well as improving our understanding of the pathophysiology of various diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.