ArticleNephron. Experimental nephrology2012
Podocytes express IL-6 and lipocalin 2/ neutrophil gelatinase-associated lipocalin in lipopolysaccharide-induced acute glomerular injury.
Article in Nephron. Experimental nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Inflammation in glomerular diseases.Frontiers in immunology · 2025Review
- IL-6 and diabetic kidney disease.Frontiers in immunology · 2024Review
- Repurposing drugs for diseases associated with podocyte dysfunction.Kidney international · 2023Review
- Parthenolide Attenuates Sepsis-Induced Acute Kidney Injury in Rats by Reducing Inflammation.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Lung Cancer Cell-Derived Secretome Mediates Paraneoplastic Inflammation and Fibrosis in Kidney in Mice.Cancers · 2020Article
- Prediction Value of Serum NGAL in the Diagnosis and Prognosis of Experimental Acute and Chronic Kidney Injuries.Biomolecules · 2020Article
- Psoriasis-Like Inflammation Induced Renal Dysfunction through the TLR/NF-BioMed research international · 2020Article
- Expression Levels of miR-30c and miR-186 in Adult Patients with Membranous Glomerulonephritis and Focal Segmental Glomerulosclerosis.International journal of nephrology and renovascular disease · 2020Article
- Heterogenous Renal Injury Biomarker Production Reveals Human Sepsis-Associated Acute Kidney Injury Subtypes.Critical care explorations · 2019Article
- Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation.JCI insight · 2018Article
- New insights into the role of renal resident cells in the pathogenesis of lupus nephritis.The Korean journal of internal medicine · 2018Review
- IL-33/ST2 Axis in Organ Fibrosis.Frontiers in immunology · 2018Review
- Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update.Frontiers in immunology · 2017Review
- miR-217 Is a Useful Diagnostic Biomarker and Regulates Human Podocyte Cells Apoptosis via Targeting TNFSF11 in Membranous Nephropathy.BioMed research international · 2017Article
- Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- IL-6 Trans-Signaling Drives Murine Crescentic GN.Journal of the American Society of Nephrology : JASN · 2016Article
- Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections.Medical microbiology and immunology · 2015Review
- Hyperglycemia abolishes the protective effect of ischemic preconditioning in glomerular endothelial cells in vitro.Physiological reports · 2015Article
- Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney.Journal of the American Society of Nephrology : JASN · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsAcute kidney injury (AKI) contributes to significant morbidity and mortality in the intensive care unit (ICU). Plasma levels of interleukin (IL)-6 predict the development of AKI and are associated with higher mortality in ICU patients with AKI. Most studies in AKI have focused on the tubulo-interstitium, despite evidence of glomerular involvement. In the following study, our goals were to investigate the expression of IL-6 and its downstream mediators in septic-induced AKI.
methodsPodocytes were treated in vitro with lipopolysaccharide (LPS) and mice were treated with LPS, and we evaluated IL-6 expression by real-time PCR, ELISA and in situ RNA hybridization.
resultsFollowing LPS stimulation, IL-6 is rapidly and highly induced in cultured podocytes and in vivo in glomeruli and infiltrating leukocytes. Surprisingly, in direct response to exogenous IL-6, podocytes produce lipocalin-2/neutrophil gelatinase-associated lipocalin (Lcn2/Ngal). LPS also potently induces Lcn2/Ngal expression in podocytes in culture and in glomeruli in vivo. Intense Lcn2/Ngal expression is also observed in IL-6 knockout mice, suggesting that while IL-6 may be sufficient to induce glomerular Lcn2/Ngal expression, it is not essential.
conclusionsThe glomerulus is involved in septic AKI, and we demonstrate that podocytes secrete key mediators of AKI including IL-6 and Lcn2/Ngal.
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