ArticleMedicine and science in sports and exercise2013
Skeletal muscle metabolism in endurance athletes with near-infrared spectroscopy.
Article in Medicine and science in sports and exercise, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07771010 (The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes Mellitus
Open the trial in the graphWho cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Muscle Oximetry in Sports Science: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Muscle mitochondrial capacity in high- and low-fitness females using near-infrared spectroscopy.Physiological reports · 2021Trial
- Trial
- Acute effect of dietary nitrate on forearm muscle oxygenation, blood volume and strength in older adults: A randomized clinical trial.PloS one · 2017Trial
- Muscle oxygen changes following Sprint Interval Cycling training in elite field hockey players.PloS one · 2015Trial
- Near infrared spectroscopy-derived muscle oxidative capacity correlates to oxidative metabolic predictors of performance in highly trained female middle-distance runners.Physiological reports · 2026Article
- Steepest near-infrared spectroscopy-derived deoxygenation slopes during arterial occlusions provide more reliable assessments of muscle mitochondrial capacity.Experimental physiology · 2026Article
- Oxidative and OExperimental physiology · 2025Article
- Muscle oxidative capacity but not specific force is greater in aerobic versus resistance trained young adults.European journal of applied physiology · 2025Article
- Cardiac workload and skeletal muscle oxygenation during incremental exercise in healthy subjects.Physiological reports · 2025Article
- Impact of sprint interval training on post-fatigue mitochondrial rate in professional boxers.European journal of applied physiology · 2025Article
- Exploring the physiological limits of aging: a case study of the male 50-km world record in the 80+ age category.Frontiers in physiology · 2025Article
- Methodological considerations on near-infrared spectroscopy derived muscle oxidative capacity.European journal of applied physiology · 2024Article
- Near-InfraRed Spectroscopy Provides a Reproducible Estimate of Muscle Aerobic Capacity, but Not Whole-Body Aerobic Power.Sensors (Basel, Switzerland) · 2024Article
- Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults.GeroScience · 2024Article
- Analysis of electrical stimulation and voluntary muscle contraction on skeletal muscle oxygen uptake and mitochondrial recovery using near-infrared spectroscopy.European journal of applied physiology · 2023Article
- Predictors of muscle hypertrophy responsiveness to electrically evoked resistance training after spinal cord injury.European journal of applied physiology · 2023Article
- Article
- Look to the stars-Is there anything that public health and rehabilitation can learn from elite sports?Frontiers in sports and active living · 2022Review
- Variability in the Aerobic Fitness-Related Dependence on Respiratory Processes During Muscle Work Is Associated With the ACE-I/D Genotype.Frontiers in sports and active living · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine whether near-infrared spectroscopy (NIRS) measurements of muscle mitochondrial function could detect the expected differences between endurance-trained athletes (n = 8) and inactive subjects (n = 8).
methodsMuscle oxygen consumption (mV˙O2) of the vastus lateralis was measured with continuous-wave NIRS using transient arterial occlusions. The recovery rate of mV˙O2 after electrical stimulation was fit to an exponential curve, with the time constant (Tc) used as an index of mitochondrial capacity. Whole-body peak oxygen uptake was determined by indirect calorimetry during a continuous ramp protocol on a cycle ergometer.
resultsWhole-body peak oxygen uptake values for endurance-trained and inactive controls were 73.5 ± 9.1 and 33.7 ± 5.9 mL·kg·min, respectively (P < 0.001). The recovery rates of mV˙O2 after exercise for endurance training were 18.4 ± 3.2 and 18.8 ± 2.5 s, whereas those for inactive controls were 32.4 ± 5.2 and 34.9 ± 5.9 s for the shallow and deep channels, respectively (P < 0.001 for comparison between groups). Resting mV˙O2 was 0.52%·s ± 0.22%·s for endurance athletes and 0.77%·s ± 0.82%·s for inactive controls (P = 0.42).
conclusionsThe recovery rates of mV˙O2 after exercise in endurance athletes were almost twofold faster than inactive subjects measured with NIRS, consistent with previous studies using muscle biopsies and magnetic resonance spectroscopy. Our results support the use of NIRS measurements of the recovery of oxygen consumption to assess muscle oxidative capacity.
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