ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: a new attractor for peripheral vascular disease?
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Endothelial senescence of the vertebral artery in the context of cervical degeneration: biomechanically driven remodeling of the hemodynamic environment.Frontiers in cell and developmental biology · 2026Review
- Regulation of Skeletal Muscle Resistance Arteriolar Tone: Temporal Variability in Vascular Responses.Journal of vascular research · 2024Article
- The development of peripheral microvasculopathy with chronic metabolic disease in obese Zucker rats: a retrograde emergence?American journal of physiology. Heart and circulatory physiology · 2022Article
- Development of Novel Fractal Method for Characterizing the Distribution of Blood Flow in Multi-Scale Vascular Tree.Frontiers in physiology · 2021Article
- Skeletal muscle performance in metabolic disease: Microvascular or mitochondrial limitation or both?Microcirculation (New York, N.Y. : 1994) · 2019Review
- A conceptual framework for predicting and addressing the consequences of disease-related microvascular dysfunction.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Altered post-capillary and collecting venular reactivity in skeletal muscle with metabolic syndrome.The Journal of physiology · 2017Article
- Cardiovascular consequences of metabolic syndrome.Translational research : the journal of laboratory and clinical medicine · 2017Review
- The superoxide dismutase mimetic tempol does not alleviate glucocorticoid-mediated rarefaction of rat skeletal muscle capillaries.Physiological reports · 2017Article
- Peripheral Blood Flow Regulation in Human Obesity and Metabolic Syndrome.Exercise and sport sciences reviews · 2016Review
- Microvascular perfusion heterogeneity contributes to peripheral vascular disease in metabolic syndrome.The Journal of physiology · 2016Review
- Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b+ cell-dependent mechanism.Stem cells translational medicine · 2015Article
- Impact of increased intramuscular perfusion heterogeneity on skeletal muscle microvascular hematocrit in the metabolic syndrome.Microcirculation (New York, N.Y. : 1994) · 2014Article
- Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion.American journal of physiology. Heart and circulatory physiology · 2014Article
- β(2)-Adrenoreceptor blockade improves early posttrauma hyperglycemia and pulmonary injury in obese rats.American journal of physiology. Heart and circulatory physiology · 2014Article
- Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma.American journal of physiology. Heart and circulatory physiology · 2014Article
- Impaired vascular KATP function attenuates exercise capacity in obese zucker rats.Microcirculation (New York, N.Y. : 1994) · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A key clinical outcome for peripheral vascular disease (PVD) in patients is a progressive decay in skeletal muscle performance and its ability to resist fatigue with elevated metabolic demand. We have demonstrated that PVD in obese Zucker rats (OZR) is partially due to increased perfusion distribution heterogeneity at successive microvascular bifurcations within skeletal muscle. As this increased heterogeneity (γ) is longitudinally present in the network, its cumulative impact is a more heterogeneous distribution of perfusion between terminal arterioles than normal, causing greater regional tissue ischemia. To minimize this negative outcome, a likely compensatory mechanism against an increased γ should be an increased temporal switching at arteriolar bifurcations to minimize downstream perfusion deficits. Using in situ cremaster muscle, we determined that temporal activity (the cumulative sum of absolute differences between successive values of γ, taken every 20 s) was lower in OZR than in control animals, and this difference was present in both proximal (1A-2A) and distal (3A-4A) arteriolar bifurcations. Although adrenoreceptor blockade (phentolamine) improved temporal activity in 1A-2A arteriolar bifurcations in OZR, this was without impact in the distal microcirculation, where only interventions against oxidant stress (Tempol) and thromboxane A(2) activity (SQ-29548) were effective. Analysis of the attractor for γ indicated that it was not only elevated in OZR but also exhibited severe reductions in range, suggesting that the ability of the microcirculation to respond to any challenge is highly restricted and may represent the major contributor to the manifestation of poor muscle performance at this age in OZR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.