ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- The role of microenvironment in the initiation and evolution of B-cell precursor acute lymphoblastic leukemia.Frontiers in oncology · 2023Review
- Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice withCells · 2022Article
- Review
- Remodeling of the Bone Marrow Stromal Microenvironment During Pathogenic Infections.Current topics in microbiology and immunology · 2021Article
- Zebrafish In Vivo Models of Cancer and Metastasis.Cold Spring Harbor perspectives in medicine · 2020Review
- Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion.Blood · 2020Article
- Toward Therapeutic Targeting of Bone Marrow Leukemic Niche Protective Signals in B-Cell Acute Lymphoblastic Leukemia.Frontiers in oncology · 2020Review
- Article
- Cell circuits and niches controlling B cell development.Immunological reviews · 2019Review
- Influenza Virus Infections and Cellular Kinases.Viruses · 2019Review
- Review
- Cell circuits between B cell progenitors and IL-7The Journal of experimental medicine · 2018Article
- PreB cells are moving on.The Journal of experimental medicine · 2018Article
- Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells.International journal of molecular sciences · 2018Review
- Regulation of Energy Metabolism during Early B Lymphocyte Development.International journal of molecular sciences · 2018Review
- Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription.The Journal of experimental medicine · 2017Article
- Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia.Leukemia · 2017Article
- A heteromeric molecular complex regulates the migration of lung alveolar epithelial cells during wound healing.Scientific reports · 2017Article
- Quantification and three-dimensional microanatomical organization of the bone marrow.Blood advances · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Progenitor B cells reside in complex bone marrow (BM) microenvironments where they receive signals for growth and maturation. We reported previously that the CXCL12-focal adhesion kinase (FAK)-VLA4 pathway plays an important role in progenitor B cell adhesion and migration. In this study, we have conditionally targeted in B cells FAK, and found that the numbers of progenitor pro-B, pre-B, and immature B cells are reduced by 30-40% in B cell-specific FAK knockout mice. When cultured in methylcellulose with IL-7 ± CXCL12, Fak-deleted pro-B cells yield significantly fewer cells and colonies. Using in situ quantitative imaging cytometry, we establish that in longitudinal femoral BM sections, pro-B cells are preferentially localized in close proximity to the endosteum of the metaphyses and the diaphysis. Fak deletion disrupts the nonrandom distribution of pro-B cells and induces the mobilization of pro-B cells to the periphery in vivo. These effects of Fak deletion on pro-B cell mobilization and localization in BM are amplified under inflammatory stress, that is, after immunization with nitrophenol-conjugated chicken γ-globulin in alum. Collectively, these studies suggest the importance of FAK in regulating pro-B cell homeostasis and maintenance of their spatial distribution in BM niches.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.