ArticleBiology letters2013
Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.
Article in Biology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- A Darwinian model for the evolution of drug resistance to long-acting PrEP during an early HIV infection.PloS one · 2026Article
- Spatially structured models of viral dynamics: a scoping review.Microbiology and molecular biology reviews : MMBR · 2025Article
- Spatial information allows inference of the prevalence of direct cell-to-cell viral infection.PLoS computational biology · 2024Article
- Review
- Understanding Willingness to Participate in HIV Biomedical Research: A Mixed Methods Investigation.AIDS and behavior · 2021Article
- Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection.Virus evolution · 2021Article
- Modeling the role of macrophages in HIV persistence during antiretroviral therapy.Journal of mathematical biology · 2020Article
- Effect of synaptic cell-to-cell transmission and recombination on the evolution of double mutants in HIV.Journal of the Royal Society, Interface · 2020Article
- Global Properties of Latent Virus Dynamics Models with Immune Impairment and Two Routes of Infection.High-throughput · 2019Article
- Article
- Synaptic transmission may provide an evolutionary benefit to HIV through modulation of latency.Journal of theoretical biology · 2018Article
- A reaction-diffusion within-host HIV model with cell-to-cell transmission.Journal of mathematical biology · 2018Article
- The role of spatial heterogeneity in the evolution of local and global infections of viruses.PLoS computational biology · 2018Article
- Fighting Cancer with Mathematics and Viruses.Viruses · 2017Review
- Pyroptosis, superinfection, and the maintenance of the latent reservoir in HIV-1 infection.Scientific reports · 2017Article
- HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell.PLoS pathogens · 2016Article
- Dynamics of HIV infection in lymphoid tissue network.Journal of mathematical biology · 2016Article
- HIV-1-Induced Small T Cell Syncytia Can Transfer Virus Particles to Target Cells through Transient Contacts.Viruses · 2015Article
- Article
- Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection.PLoS computational biology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.