ArticleArteriosclerosis, thrombosis, and vascular biology2013
Subsequent development of fibroatheromas with inflamed fibrous caps can be predicted by intracoronary near infrared spectroscopy.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06606821 (The Effects of Tirzepatide on Coronary Plaque Lipid Content and Myocardial Microvascular Function in Overweight and Obese People With Coronary Disease - The IDEAL-COR Study), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Tirzepatide on Coronary Plaque Lipid Content and Myocardial Microvascular Function in Overweight and Obese People With Coronary Disease - The IDEAL-COR Study
Who cites it
13 citing papers in PubMed.
- Wall shear stress-related plaque growth of lipid-rich plaques in human coronary arteries: an near-infrared spectroscopy and optical coherence tomography study.Cardiovascular research · 2023Article
- Evolving concepts of the vulnerable atherosclerotic plaque and the vulnerable patient: implications for patient care and future research.Nature reviews. Cardiology · 2023Review
- Near-infrared spectroscopy to predict plaque progression in plaque-free artery regions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Article
- Near-Infrared Spectroscopy Intravascular Ultrasound Imaging: State of the Art.Frontiers in cardiovascular medicine · 2020Review
- Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile: Findings From a Familial Hypercholesterolemia Pig Model.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Modelling of atherosclerosis in genetically modified animals.American journal of translational research · 2019Review
- Intracoronary near-infrared spectroscopy: an overview of the technology, histologic validation, and clinical applications.Global cardiology science & practice · 2016Review
- Systems Biology and Noninvasive Imaging of Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2016Review
- Recent highlights of ATVB: diabetes mellitus.Arteriosclerosis, thrombosis, and vascular biology · 2014Review
- New insights into the vulnerable plaque from imaging studies.Current atherosclerosis reports · 2014Review
- Imaging atherosclerosis and risk of plaque rupture.Current atherosclerosis reports · 2013Review
- Concept of atherosclerosis velocity: is it a better measure of cardiovascular risk?Iranian journal of medical sciences · 2013Review
- Porcine models of accelerated coronary atherosclerosis: role of diabetes mellitus and hypercholesterolemia.Journal of diabetes research · 2013Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo prospectively evaluate whether the development of fibroatheromas exhibiting features of potential instability can be detected and predicted by serial invasive imaging. METHODS AND
resultsMultivessel intravascular ultrasound and near infrared spectroscopy (NIRS) were performed in diabetic/hypercholesterolemic pigs 3, 6, and 9 months after induction. Animals were euthanized at 9 months and histological/immunohistochemical evaluation of the arteries was performed (n=304 arterial segments). Intravascular ultrasound demonstrated, over time, a progressive increase in plaque + media and necrotic core areas and positive vascular remodeling. By histology, NIRS+ lesions were significantly more likely to be a high-risk fibroatheroma (P=0.0001) containing larger plaque (P<0.0001) and necrotic core areas (P<0.0019) and thinner fibrous caps (P=0.04). NIRS + fibroatheromas possessed a greater concentration of inflammatory cells demonstrating protease activity (P=0.006), and proliferating (P=0.016), and apoptotic cells (P=0.04) within the fibrous cap. Eighty-eight percent of NIRS+ lesions at 3 and 6 months subsequently developed into a fibroatheroma at 9 months (P<0.01). By multivariate analysis NIRS positivity at 6 months predicted the subsequent presence of a fibroatheroma at 9 months (P=0.005; odds ratio, 2.71).
conclusionsThe future development of inflamed fibroatheromas with thinner fibrous caps, greater plaque, and necrotic core areas, and posessing characteristics of increased plaque instability were detected by intravascular ultrasound/NIRS imaging.
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23288155What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.