ArticleInternational urology and nephrology2013
The influence of ethanol intake on RhoA/Rho kinase signaling pathway in corpus cavernosum of OLETF rats.
Article in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Pomegranate juice causes a partial improvement through lowering oxidative stress for erectile dysfunction in streptozotocin-diabetic rat.International journal of impotence research · 2016Article
- The effect of sub-chronic systemic ethanol treatment on corpus cavernosal smooth muscle contraction: the contribution of RhoA/Rho-kinase.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
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8 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of the ethanol on corpus cavernosum of the type 2 diabetes mellitus (type 2 DM) rat, since previous studies have reported the positive effect of moderate drinking on type 2 DM and endothelial function.
methodsOtsuka Long Evans Tokushima Fatty (OLETF, n = 28) and Long Evans Tokushima Otsuka (LETO, n = 28) male rats were assigned to four groups: control (LETO, n = 14), control/ethanol (LETO with ethanol, n = 14), fatty (OLETF, n = 14) and fatty/ethanol (OLETF with ethanol, n = 14). The control/ethanol and fatty/ethanol groups were fed Lieber-DeCarli Regular EtOH. After 10 weeks, an intraperitoneal glucose tolerance test (IPGTT) was performed. RT-PCR and Western blot analyses of the RhoA/Rho kinase in the corpus cavernosum were performed. The expression of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) in the corpus cavernosum was evaluated by immunohistochemistry.
resultsAfter a 10-week ethanol intake, the body weight and the IPGTT of the fatty/ethanol group were significantly lower compared with the fatty group (p < 0.05). A significantly increased mRNA and protein expression in the fatty group was observed compared with the control group by RT-PCR and Western blot analyses (p < 0.05): A significantly decreased expression was observed in the fatty/ethanol group compared with the fatty group (p < 0.05). The significantly increased expression of eNOS was observed in the fatty/ethanol group compared with the fatty group by immunohistochemistry.
conclusionsLong-term ethanol intake may preserve the erectile function in type 2 DM through the down-regulation of the RhoA/Rho kinase pathway.
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