ArticleObesity surgery2013
Change in levels of C-reactive protein (CRP) and serum cortisol in morbidly obese patients after laparoscopic sleeve gastrectomy.
Article in Obesity surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effect of Bariatric Surgery on Serum Inflammatory Factors of Obese Patients: a Systematic Review and Meta-Analysis.Obesity surgery · 2019Pooled it
- Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low-energy diet.Diabetes, obesity & metabolism · 2025Trial
- Trial
- Hair Cortisone Levels and the Metabolic Syndrome: Stronger Links in Younger Compared to Older Adults.The Journal of clinical endocrinology and metabolism · 2025Article
- Systemic Inflammatory Response Index Is Associated With Insufficient Weight Loss After Bariatric Surgery.World journal of surgery · 2025Observational
- Impact of BMI Reduction After Sleeve Surgery on ESR and CRP Levels in Patients with Obesity.Obesity surgery · 2025Observational
- Sex-differential testosterone response to long-term weight loss.International journal of obesity (2005) · 2024Observational
- Cortisol/DHEA ratio in morbidly obese patients before and after bariatric surgery: Relation to metabolic parameters and cardiovascular performance.International journal of obesity (2005) · 2022Article
- Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice.Frontiers in endocrinology · 2022Article
- The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy.Frontiers in surgery · 2022Article
- Assessment of Risk Factors Associated with Cardiovascular Diseases in Overweight Women.Nutrients · 2021Article
- Laparoscopic left hemihepatectomy combined with right lateral hepatic lobectomy in pigs: surgical approach and comparative study of the inflammatory response versus open surgery.Veterinary research forum : an international quarterly journal · 2021Article
- The Association Of Serum Cortisol Level With Microalbuminuria In Patients With Type 2 Diabetes And Prediabetes.International journal of medical sciences · 2020Article
- The immune remodel: Weight loss-mediated inflammatory changes to obesity.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Metabolic and Endocrine Consequences of Bariatric Surgery.Frontiers in endocrinology · 2019Review
- Telemedical assessment of the level of energy expenditure in overweight and obese individuals.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2017Article
- Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity.International journal of obesity (2005) · 2016Article
- C-Reactive protein and procalcitonin for the early detection of postoperative complications after sleeve gastrectomy: preliminary study in 97 patients.Surgical endoscopy · 2015Article
- Impact of bariatric surgery on carotid artery inflammation and the metabolic activity in different adipose tissues.Medicine · 2015Article
- The impact of bariatric surgery on nutritional status of patients.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC-Reactive protein (CRP) has been associated with the macro- and microvascular effects of hypertension and diabetes mellitus. Referring to serum cortisol, it has been proposed to contribute to the pathogenesis of metabolic syndrome, and it has been demonstrated that weight loss normalizes cortisol levels and improves insulin resistance. The aims of this study were to analyze CRP and cortisol levels pre- and postoperatively in morbidly obese patients undergoing a laparoscopic sleeve gastrectomy and to correlate them with weight loss and parameters associated with cardiovascular risk.
methodsA prospective study of all the morbidly obese patients undergoing laparoscopic sleeve gastrectomy as bariatric procedure between October 2007 and May 2011 was performed.
resultsA total of 40 patients were included in the study. CRP levels decreased significantly 12 months after surgery (median reduction of 8.9 mg/l; p = 0.001). Serum cortisol levels decreased significantly 6 months after surgery (median reduction of 34.9 μg/dl; p = 0.001). CRP values reached the normal range (<5 mg/l) 1 year after surgery. Referring to cortisol, a significant association was observed with the cardiovascular risk predictor (triglyceride/high-density lipoprotein cholesterol ratio) from the 6th month after surgery onward (Pearson correlation coefficient, 0.559; p = 0.008).
conclusionCRP levels are increased preoperatively and in the postoperative course up to 1 year after surgery. Serum cortisol levels remain elevated until the 6th month after surgery. From this moment onward, serum cortisol is associated with the cardiovascular risk predictor reflecting the cardiovascular risk decreasement during the weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.