ArticleFrontiers in genetics2013
How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Increasing Educational Inequality in Biological Aging Among U.S. Adults Aged 50-79 From 1988-1994 to 2015-2018.Demography · 2025Article
- How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.Frontiers in aging · 2024Article
- Association Between Late-Life Weight Change and Dementia: A Population-based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion.Aging · 2019Article
- "Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
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- Predictors and Implications of Accelerated Cognitive Aging.Biodemography and social biology · 2018Article
- A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.Genetic epidemiology · 2017Article
- Identification of polymorphisms in cancer patients that differentially affect survival with age.Aging · 2017Article
- Article
- Predicting all-cause mortality from basic physiology in the Framingham Heart Study.Aging cell · 2016Article
- How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Biogerontology · 2016Review
- How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.North American actuarial journal : NAAJ · 2016Article
- Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.Frontiers in public health · 2016Article
- Aging in the context of cohort evolution and mortality selection.Demography · 2014Article
- A clinical frailty index in aging mice: comparisons with frailty index data in humans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Aging is not a disease: implications for intervention.Aging and disease · 2014Review
- Comparison of alternate scoring of variables on the performance of the frailty index.BMC geriatrics · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveThe influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. The age trajectories of these processes contain important information about mechanisms linking aging, health, and lifespan. The objective of this paper is to investigate regularities of aging changes in different groups of individuals, including individuals with different genetic background, as well as their connections with health and lifespan. DATA AND
methodTo reach this objective we used longitudinal data on four physiological variables, information about health and lifespan collected in the Framingham Heart Study (FHS), data on longevity alleles detected in earlier study, as well as methods of statistical modeling.
resultsWe found that phenotypes of exceptional longevity and health are linked to distinct types of changes in physiological indices during aging. We also found that components of aging changes differ in groups of individuals with different genetic background.
conclusionsThese results suggest that factors responsible for exceptional longevity and health are not necessary the same, and that postponing aging changes is associated with extreme longevity. The genetic factors which increase lifespan are associated with physiological changes typical of healthy and long-living individuals, smaller mortality risks from cancer and CVD and better estimates of adaptive capacity in statistical modeling. This indicates that extreme longevity and health related traits are likely to be less heterogeneous phenotypes than lifespan, and studying these phenotypes separately from lifespan may provide additional information about mechanisms of human aging and its relation to chronic diseases and lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.