SynthesisPloS one2013
The role of statins in prevention and treatment of community acquired pneumonia: a systematic review and meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Intragastric Botulinum Toxin A Injection Is an Effective Obesity Therapy for Patients with BMI > 40 kg/mObesity surgery · 2020Pooled it
- Effect on non-vascular outcomes of lowering LDL cholesterol in patients with chronic kidney disease: results from the Study of Heart and Renal Protection.BMC nephrology · 2017Trial
- Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial.The Lancet. Respiratory medicine · 2016Trial
- Rosuvastatin for sepsis-associated acute respiratory distress syndrome.The New England journal of medicine · 2014Trial
- Reducing the complications from community acquired pneumonia: a review.Journal of thoracic disease · 2026Review
- Continuation of Statins after Acute Intracerebral Haemorrhage and Survival: The Role of Inflammation, Infection, and Indication Bias.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Routine statins use is associated with less adverse outcome in patients above 70 years of age admitted to hospital with COVID-19.BMC geriatrics · 2023Article
- Cardiovascular Complications in Community-Acquired Pneumonia.Microorganisms · 2022Review
- Association between cardiometabolic risk factors and COVID-19 susceptibility, severity and mortality: a review.Journal of diabetes and metabolic disorders · 2021Review
- Prior Statin Use and Risk of Mortality and Severe Disease From Coronavirus Disease 2019: A Systematic Review and Meta-analysis.Open forum infectious diseases · 2021Article
- Pneumonia prevention in the elderly patients: the other sides.Aging clinical and experimental research · 2021Article
- Association Between Chronic Statin Use and 30-Day Mortality in Hospitalized Patients With COVID-19.Mayo Clinic proceedings. Innovations, quality & outcomes · 2021Article
- Hyperlipidaemia and mortality among patients hospitalised with pneumonia: retrospective cohort and propensity score matched study.BMJ open respiratory research · 2021Article
- Statins and PCSK9 inhibitors: What is their role in coronavirus disease 2019?Medical hypotheses · 2021Review
- Effects of statins on clinical outcomes in hospitalized patients with community-acquired pneumonia.The Journal of international medical research · 2020Article
- Simvastatin decreases the silver resistance of E. faecalis through compromising the entrapping function of extracellular polymeric substances against silver.World journal of microbiology & biotechnology · 2020Article
- Statin Use and the Point Prevalence of Antibiotics in Ambulatory Patients with Diabetes in the National Health and Nutrition Examination Survey (NHANES) 2003-2012.Antibiotics (Basel, Switzerland) · 2019Article
- Statin therapy in patients with community-acquired pneumonia.Clinical medicine (London, England) · 2017Observational
- Hospitalized Patients with Acute Pneumonia.Hospital medicine clinics · 2017Review
- South African guideline for the management of community-acquired pneumonia in adults.Journal of thoracic disease · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging epidemiological evidence suggests that statins may reduce the risk of community-acquired pneumonia (CAP) and its complications. PURPOSE: Performed a systematic review to address the role of statins in the prevention or treatment of CAP. DATA SOURCE: Ovid MEDLINE, Cochrane, EMBASE, ISI Web of Science, and Scopus from inception through December 2011 were searched for randomized clinical trials, cohort and case-control studies. STUDY SELECTION: Two authors independently reviewed studies that examined the role of statins in CAP. DATA EXTRACTION: Data about study characteristics, adjusted effect-estimates and quality characteristics was extracted. DATA SYNTHESIS: Eighteen studies corresponding to 21 effect-estimates (eight and 13 of which addressed the preventive and therapeutic roles of statins, respectively) were included. All studies were of good methodological quality. Random-effects meta-analyses of adjusted effect-estimates were used. Statins were associated with a lower risk of CAP, 0.84 (95% CI, 0.74-0.95), I(2) = 90.5% and a lower short-term mortality in patients with CAP, 0.68 (95% CI, 0.59-0.78), I(2) = 75.7%. Meta-regression did not identify sources of heterogeneity. A funnel plot suggested publication bias in the treatment group, which was adjusted by a novel regression method with a resultant effect-estimate of 0.85 (95% CI, 0.77-0.93). Sensitivity analyses using the rule-out approach showed that it is unlikely that the results were due to an unmeasured confounder.
conclusionsOur meta-analysis reveals a beneficial role of statins for the risk of development and mortality associated with CAP. However, the results constitute very low quality evidence as per the GRADE framework due to observational study design, heterogeneity and publication bias.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.