ReviewClinical chemistry2013
Data submission and quality in microarray-based microRNA profiling.
Review in Clinical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and predictors of data and code sharing in the medical and health sciences: systematic review with meta-analysis of individual participant data.BMJ (Clinical research ed.) · 2023Pooled it
- Open science interventions to improve reproducibility and replicability of research: a scoping review.Royal Society open science · 2025Article
- Data sharing practices and data availability upon request differ across scientific disciplines.Scientific data · 2021Article
- No Dataset Left Behind: Mechanistic Insights into Thyroid Receptor Signaling Through Transcriptomic Consensome Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2020Article
- Article
- Improving the discoverability, accessibility, and citability of omics datasets: a case report.Journal of the American Medical Informatics Association : JAMIA · 2017Article
- MicroRNAs in metabolism.Acta physiologica (Oxford, England) · 2017Review
- Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology (Review).International journal of oncology · 2016Review
- Comparison of different extraction techniques to profile microRNAs from human sera and peripheral blood mononuclear cells.BMC genomics · 2014Article
- Integrating microRNA and mRNA expression profiles in response to radiation-induced injury in rat lung.Radiation oncology (London, England) · 2014Article
- HIV-1 Tat- and Vpr-responsive microRNAs of neuronal cells.The Journal of biological chemistry · 2014Article
- The potential of microRNAs in personalized medicine against cancers.BioMed research international · 2014Review
- Article
- miRNA dysregulation in cancer: towards a mechanistic understanding.Frontiers in genetics · 2014Review
- Methods and compositions for amplification and detection of microRNAs (miRNAs) and noncoding RNAs (ncRNAs) using the signature sequence amplification method (SSAM).Recent advances in DNA & gene sequences · 2014Article
- From microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment (Review).International journal of oncology · 2013Review
- Article
- More data, please!Clinical chemistry · 2013Article
- Standardization of sample collection, isolation and analysis methods in extracellular vesicle research.Journal of extracellular vesicles · 2013Article
- Comparison of Methods for miRNA Extraction from Plasma and Quantitative Recovery of RNA from Cerebrospinal Fluid.Frontiers in genetics · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
backgroundPublic sharing of scientific data has assumed greater importance in the omics era. Transparency is necessary for confirmation and validation, and multiple examiners aid in extracting maximal value from large data sets. Accordingly, database submission and provision of the Minimum Information About a Microarray Experiment (MIAME)(3) are required by most journals as a prerequisite for review or acceptance.
methodsIn this study, the level of data submission and MIAME compliance was reviewed for 127 articles that included microarray-based microRNA (miRNA) profiling and were published from July 2011 through April 2012 in the journals that published the largest number of such articles--PLOS ONE, the Journal of Biological Chemistry, Blood, and Oncogene--along with articles from 9 other journals, including Clinical Chemistry, that published smaller numbers of array-based articles.
resultsOverall, data submission was reported at publication for <40% of all articles, and almost 75% of articles were MIAME noncompliant. On average, articles that included full data submission scored significantly higher on a quality metric than articles with limited or no data submission, and studies with adequate description of methods disproportionately included larger numbers of experimental repeats. Finally, for several articles that were not MIAME compliant, data reanalysis revealed less than complete support for the published conclusions, in 1 case leading to retraction.
conclusionsThese findings buttress the hypothesis that reluctance to share data is associated with low study quality and suggest that most miRNA array investigations are underpowered and/or potentially compromised by a lack of appropriate reporting and data submission.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.