ArticleDiabetes care2013
Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations.Nutrients · 2021Pooled it
- Pooled it
- Effects of Lifestyle Modification and Anti-diabetic Medicine on Prediabetes Progress: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2019Pooled it
- Pooled it
- Chewing betel quid and the risk of metabolic disease, cardiovascular disease, and all-cause mortality: a meta-analysis.PloS one · 2013Pooled it
- Insulin secretion and sensitivity in healthy adults with low vitamin D are not affected by high-dose ergocalciferol administration: a randomized controlled trial.The American journal of clinical nutrition · 2015Trial
- Serum 25-hydroxyvitamin D levels and risk of type 2 diabetes according to glycemic status: a prospective cohort study.Nutrition & diabetes · 2026Article
- Serum vitamin D is substantially reduced and predicts flares in diabetic retinopathy patients.Journal of diabetes investigation · 2024Observational
- Unraveling the dual threat: sarcopenia and insufficient physical activity in diabetes risk.Frontiers in endocrinology · 2024Article
- Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors.The Journal of clinical endocrinology and metabolism · 2023Article
- Vitamin D and Diabetic Kidney Disease.International journal of molecular sciences · 2023Review
- An Overview of Systematic Reviews of the Role of Vitamin D on Inflammation in Patients with Diabetes and the Potentiality of Its Application on Diabetic Patients with COVID-19.International journal of molecular sciences · 2022Review
- Role of vitamin D in diabetic retinopathy: Pathophysiological and clinical aspects.Reviews in endocrine & metabolic disorders · 2021Review
- Hypovitaminosis D and the endocrine phenotype of COVID-19.Endocrine · 2021Review
- Role of Vitamin D Status in Diabetic Patients with Renal Disease.Medicina (Kaunas, Lithuania) · 2019Review
- Levels of 25-hydroxyvitamin DMetabolic brain disease · 2019Article
- Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study.PloS one · 2018Article
- The association of vitamin D deficiency and glucose control among diabetic patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017Article
- Vitamin D and spinal cord injury: should we care?Spinal cord · 2016Review
- Impact of vitamin D deficiency on maternal and birth outcomes in the Saudi population: a cross-sectional study.BMC pregnancy and childbirth · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the association between vitamin D status and the risk of incident impaired fasting glucose (IFG) and diabetes in a population-based cohort of diabetes-free subjects. RESEARCH DESIGN AND
methodsIn a historical prospective cohort study of subjects from the Clalit Health Services database, which includes information on nearly 4 million people, diabetes-free subjects aged 40-70 years with serum 25-hydroxycholecalciferol (25-OHD) measurements available were followed for 2 years to assess the development of IFG and diabetes in five 25-OHD subgroups: ≥25, 25.1-37.5, 37.6-50, 50.1-75, and >75 nmol/L.
resultsThe baseline cohort included 117,960 adults: 83,526 normoglycemic subjects and 34,434 subjects with IFG. During follow-up, 8,629 subjects (10.3% of the normoglycemic group) developed IFG, and 2,162 subjects (1.8% of the total cohort) progressed to diabetes. A multivariable model adjusted for age, sex, population group, immigrant status, BMI, season of vitamin D measurement, LDL and HDL cholesterol, triglycerides, estimated glomerular filtration rate, history of hypertension or cardiovascular disease, Charlson comorbidity index, smoking, and socioeconomic status revealed an inverse association between 25-OHD and the risk of progression to IFG and diabetes. The odds of transitioning from normoglycemia to IFG, from normoglycemia to diabetes, and from IFG to diabetes in subjects with a 25-OHD level ≤25 nmol/L were greater than those of subjects with a 25-OHD level >75 nmol/L [odds ratio 1.13 (95% CI 1.03-1.24), 1.77 (1.11-2.83), and 1.43 (1.16-1.76), respectively].
conclusionsVitamin D deficiency appears to be an independent risk factor for the development of IFG and diabetes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.