ArticleJournal of biomedical materials research. Part A2013
Neural responses to electrical stimulation on patterned silk films.
Article in Journal of biomedical materials research. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair.Materials today. Bio · 2025Article
- Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration.Burns & trauma · 2025Review
- 3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer's disease.Molecular psychiatry · 2023Article
- Graphene Oxide-Coated Patterned Silk Fibroin Films Promote Cell Adhesion and Induce Cardiomyogenic Differentiation of Human Mesenchymal Stem Cells.Biomolecules · 2023Article
- Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System.Pharmaceutics · 2021Review
- Soft Devices for High-Resolution Neuro-Stimulation: The Interplay Between Low-Rigidity and Resolution.Frontiers in medical technology · 2021Review
- Effect of Electrical and Electromechanical Stimulation on PC12 Cell Proliferation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2021Article
- Electrically Stimulated Tunable Drug Delivery From Polypyrrole-Coated Polyvinylidene Fluoride.Frontiers in chemistry · 2021Article
- A Long-Living Bioengineered Neural Tissue Platform to Study Neurodegeneration.Macromolecular bioscience · 2020Article
- Film interface for drug testing for delivery to cells in culture and in the brain.Acta biomaterialia · 2019Article
- Cortical Network Synchrony Under Applied Electrical FieldFrontiers in neuroscience · 2018Article
- Nanoscale probing of electron-regulated structural transitions in silk proteins by near-field IR imaging and nano-spectroscopy.Nature communications · 2016Article
- Physical and biological regulation of neuron regenerative growth and network formation on recombinant dragline silks.Biomaterials · 2015Article
- Silk-tropoelastin protein films for nerve guidance.Acta biomaterialia · 2015Article
- Silk Nanofiber Hydrogels with Tunable Modulus to Regulate Nerve Stem Cell Fate.Journal of materials chemistry. B · 2014Article
- Film-based Implants for Supporting Neuron-Electrode Integrated Interfaces for The Brain.Advanced functional materials · 2014Article
- The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice.BioMed research international · 2014Article
- Recent advances in developing insect natural products as potential modern day medicines.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Transdermal delivery devices: fabrication, mechanics and drug release from silk.Small (Weinheim an der Bergstrasse, Germany) · 2013Article
- Advances in tissue engineering of peripheral nerve and tissue innervation - a systematic review.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Peripheral nerve injury is a critical issue for patients with trauma. Following injury, incomplete axon regeneration or misguided axon innervation into tissue will result in loss of sensory and motor functions. The objective of this study was to examine axon outgrowth and axon alignment in response to surface patterning and electrical stimulation. To accomplish our objective, metal electrodes with dimensions of 1.5 mm × 4 cm, were sputter coated onto micropatterned silk protein films, with surface grooves 3.5 μm wide × 500 nm deep. P19 neurons were seeded on the patterned electronic silk films and stimulated at 120 mV, 1 kHz, for 45 min each day for 7 days. Responses were compared with neurons on flat electronic silk films, patterned silk films without stimulation, and flat silk films without stimulation. Significant alignment was found on the patterned film groups compared with the flat film groups. Axon outgrowth was greater (p < 0.05) on electronic films on days 5 and 7 compared with the unstimulated groups. In conclusion, electrical stimulation, at 120 mV, 1 kHz, for 45 min daily, in addition to surface patterning, of 3.5 μm wide × 500 nm deep grooves, offered control of nerve axon outgrowth and alignment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.