ArticleMagnetic resonance in medicine2014
Noncontrast skeletal muscle oximetry.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Nine-grid segmentation strategy for photoacoustic imaging of microcirculation oxygenation dynamics in the thenar muscle.Photoacoustics · 2026Article
- 24-hourFrontiers in transplantation · 2026Article
- Cerebral oxygen extraction across different exercise intensities: Role of arterialExperimental physiology · 2025Article
- Quantitative Assessment of Peripheral Oxidative Metabolism With a New DynamicJournal of magnetic resonance imaging : JMRI · 2024Article
- Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCOJournal of neurochemistry · 2024Article
- Regional skeletal muscle perfusion distribution in diabetic feet may differentiate short-term healed foot ulcers from non-healed ulcers.European radiology · 2023Article
- Energy supply per neuron is constrained by capillary density in the mouse brain.Frontiers in integrative neuroscience · 2022Article
- From a Demand-Based to a Supply-Limited Framework of Brain Metabolism.Frontiers in integrative neuroscience · 2022Article
- Pilot study of contrast-free MRI reveals significantly impaired calf skeletal muscle perfusion in diabetes with incompressible peripheral arteries.Vascular medicine (London, England) · 2021Article
- Quantification of myocardial oxygen extraction fraction: A proof-of-concept study.Magnetic resonance in medicine · 2021Article
- Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model.Acta diabetologica · 2020Article
- Feasibility of MRI based oxygenation imaging for the assessment of acute limb ischemia.Annals of translational medicine · 2020Article
- Quantitative and Dynamic MRI Measures of Peripheral Vascular Function.Frontiers in physiology · 2020Review
- Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus.Journal of magnetic resonance imaging : JMRI · 2019Article
- Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption.Magnetic resonance in medicine · 2018Article
- A Kernel-Based Low-Rank (KLR) Model for Low-Dimensional Manifold Recovery in Highly Accelerated Dynamic MRI.IEEE transactions on medical imaging · 2017Article
- Multiorgan, Multimodality Imaging in Cardiometabolic Disease.Circulation. Cardiovascular imaging · 2017Review
- Monitoring clinical progression with mitochondrial disease biomarkers.Brain : a journal of neurology · 2017Review
- Oximetric angiosome imaging in diabetic feet.Journal of magnetic resonance imaging : JMRI · 2016Article
- The role of perfusion in the oxygen extraction capability of skin and skeletal muscle.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThe objective of this study was to develop a new noncontrast method to directly quantify regional skeletal muscle oxygenation.
methodsThe feasibility of the method was examined in five healthy volunteers using a 3 T clinical MRI scanner, at rest and during a sustained isometric contraction. The perfusion of skeletal muscle of the calf was measured using an arterial spin labeling method, whereas the oxygen extraction fraction of the muscle was measured using a susceptibility-based MRI technique.
resultsIn all volunteers, the perfusion in soleus muscle increased significantly from 6.5 ± 2.0 mL (100 g min)(-1) at rest to 47.9 ± 7.7 mL (100 g min)(-1) during exercise (P < 0.05). Although the corresponding oxygen extraction fraction did not change significantly, the rate of oxygen consumption increased from 0.43 ± 0.13 to 4.2 ± 1.5 mL (100 g min)(-1) (P < 0.05). Similar results were observed in gastrocnemius muscle but with greater oxygen extraction fraction increase than the soleus muscle.
conclusionThis is the first MR oximetry developed for quantification of regional skeletal muscle oxygenation. A broad range of medical conditions could benefit from these techniques, including cardiology, gerontology, kinesiology, and physical therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.