ArticleCell death and differentiation2013
pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737.
Article in Cell death and differentiation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- 4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells.Foods (Basel, Switzerland) · 2021Article
- Artificial intelligence and digital pathology: Opportunities and implications for immuno-oncology.Biochimica et biophysica acta. Reviews on cancer · 2021Review
- E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.EMBO reports · 2018Article
- Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL.Cell death & disease · 2016Article
- Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin.Journal of thoracic disease · 2015Article
- Transcriptional control of stem cell fate by E2Fs and pocket proteins.Frontiers in genetics · 2015Review
- The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA.Cell death & disease · 2014Article
- Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.Molecular & cellular oncology · 2014Review
- Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis.PloS one · 2014Article
- Evaluation and critical assessment of putative MCL-1 inhibitors.Cell death and differentiation · 2013Article
- Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival.Cell cycle (Georgetown, Tex.) · 2013Article
- Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.Cell death & disease · 2013Article
- Decoding and unlocking the BCL-2 dependency of cancer cells.Nature reviews. Cancer · 2013Review
- To live or let die - complexity within the E2F1 pathway.Molecular & cellular oncologyReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Bcl-2 family members control caspase activity by regulating mitochondrial permeability, caspases can, in turn, amplify the apoptotic process upstream of mitochondria by ill-characterized mechanisms. We herein show that treatment with a potent inhibitor of Bcl-2 and Bcl-xL, ABT-737, triggers caspase-dependent induction of the BH3-only protein, Mcl-1 inhibitor, Noxa. RNA interference experiments reveal that induction of Noxa, and subsequent cell death, rely not only on the transcription factor E2F-1 but also on its regulator pRb. In response to ABT-737, pRb is cleaved by caspases into a p68Rb form that still interacts with E2F-1. Moreover, pRb occupies the noxa promoter together with E2F-1, in a caspase-dependent manner upon ABT-737 treatment. Thus, caspases contribute to trigger the mitochondrial apoptotic pathway by coupling Bcl-2/Bcl-xL inhibition to that of Mcl-1, via the pRb/E2F-1-dependent induction of Noxa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.