ReviewBiophysical journal2013
There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton.
Review in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity.Seminars in cell & developmental biology · 2019Review
- Model First and Ask Questions Later: Confessions of a Reformed Experimentalist.Journal of biomechanical engineering · 2019Article
- Probing the Occurrence of Soluble Oligomers through Amyloid Aggregation Scaling Laws.Biomolecules · 2018Article
- Reconsidering an active role for G-actin in cytoskeletal regulation.Journal of cell science · 2018Review
- Multivalent Molecules as Modulators of RNA Granule Size and Composition.Biophysical journal · 2017Article
- Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.PLoS computational biology · 2017Article
- Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer.Scientific reports · 2016Article
- Strong Inference in Mathematical Modeling: A Method for Robust Science in the Twenty-First Century.Frontiers in microbiology · 2016Article
- Quantifying Limits on Replication, Death, and Quiescence of Mycobacterium tuberculosis in Mice.Frontiers in microbiology · 2016Article
- The value of mechanistic biophysical information for systems-level understanding of complex biological processes such as cytokinesis.Biophysical journal · 2014Review
- Membrane related dynamics and the formation of actin in cells growing on micro-topographies: a spatial computational model.BMC systems biology · 2014Article
- Actin-myosin spatial patterns from a simplified isotropic viscoelastic model.Biophysical journal · 2014Article
- Computational modeling of subcellular transport and signaling.Current opinion in structural biology · 2014Review
- Regulation of actin by ion-linked equilibria.Biophysical journal · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Mathematical modeling has established its value for investigating the interplay of biochemical and mechanical mechanisms underlying actin-based motility. Because of the complex nature of actin dynamics and its regulation, many of these models are phenomenological or conceptual, providing a general understanding of the physics at play. But the wealth of carefully measured kinetic data on the interactions of many of the players in actin biochemistry cries out for the creation of more detailed and accurate models that could permit investigators to dissect interdependent roles of individual molecular components. Moreover, no human mind can assimilate all of the mechanisms underlying complex protein networks; so an additional benefit of a detailed kinetic model is that the numerous binding proteins, signaling mechanisms, and biochemical reactions can be computationally organized in a fully explicit, accessible, visualizable, and reusable structure. In this review, we will focus on how comprehensive and adaptable modeling allows investigators to explain experimental observations and develop testable hypotheses on the intracellular dynamics of the actin cytoskeleton.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.